C-13 Labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeae

Jien Wu, Hai-Bao Zhang, Jin-Ling Xu, Russell J. Cox, Thomas J. Simpson, Lian-Hui Zhang

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

Abstract

The structure of zeamine, a novel polyamino-amide antibiotic metabolite of Dickeya zeae has been established by NMR and detailed MS analyses; labelling studies with C-13-labelled acetates suggest that the repeating secondary amine containing motif may be biosynthesised via a modular PKS containing aminotransferase domains.

Original languageEnglish
Pages (from-to)333-335
Number of pages3
JournalChemical Communications
Volume46
Issue number2
DOIs
Publication statusPublished - 2010

Cite this