C-13 Labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeae

Jien Wu; Hai-Bao Zhang; Jin-Ling Xu; Russell J. Cox; Thomas J. Simpson; Lian-Hui Zhang

doi:10.1039/b916307g

C-13 Labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeae

Jien Wu, Hai-Bao Zhang, Jin-Ling Xu, Russell J. Cox, Thomas J. Simpson, Lian-Hui Zhang

Research output: Contribution to journal › Article (Academic Journal)

28 Citations (Scopus)

Abstract

The structure of zeamine, a novel polyamino-amide antibiotic metabolite of Dickeya zeae has been established by NMR and detailed MS analyses; labelling studies with C-13-labelled acetates suggest that the repeating secondary amine containing motif may be biosynthesised via a modular PKS containing aminotransferase domains.

Original language	English
Pages (from-to)	333-335
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	2
DOIs	https://doi.org/10.1039/b916307g
Publication status	Published - 2010

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10.1039/b916307g

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title = "C-13 Labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeae",

abstract = "The structure of zeamine, a novel polyamino-amide antibiotic metabolite of Dickeya zeae has been established by NMR and detailed MS analyses; labelling studies with C-13-labelled acetates suggest that the repeating secondary amine containing motif may be biosynthesised via a modular PKS containing aminotransferase domains.",

author = "Jien Wu and Hai-Bao Zhang and Jin-Ling Xu and Cox, {Russell J.} and Simpson, {Thomas J.} and Lian-Hui Zhang",

year = "2010",

doi = "10.1039/b916307g",

language = "English",

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pages = "333--335",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

number = "2",

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C-13 Labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeae. / Wu, Jien; Zhang, Hai-Bao; Xu, Jin-Ling; Cox, Russell J.; Simpson, Thomas J.; Zhang, Lian-Hui.

In: Chemical Communications, Vol. 46, No. 2, 2010, p. 333-335.

Research output: Contribution to journal › Article (Academic Journal)

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AU - Simpson, Thomas J.

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AB - The structure of zeamine, a novel polyamino-amide antibiotic metabolite of Dickeya zeae has been established by NMR and detailed MS analyses; labelling studies with C-13-labelled acetates suggest that the repeating secondary amine containing motif may be biosynthesised via a modular PKS containing aminotransferase domains.

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DO - 10.1039/b916307g

M3 - Article (Academic Journal)

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