C2-Alkenylation of N-heteroaromatic compounds: Via Brønsted acid catalysis

Giacomo Crisenza, Elizabeth M. Dauncey, John Bower

Research output: Contribution to journalArticle (Academic Journal)peer-review

42 Citations (Scopus)
541 Downloads (Pure)

Abstract

Substituted heteroaromatic compounds, especially those based on pyridine, hold a privileged position within drug discovery and medicinal chemistry. However, functionalisation of the C2 position of 6-membered heteroarenes is challenging because of (a) the difficulties of installing a halogen at this site and (b) the instability of C2 heteroaryl-metal reagents. Here we show that C2-alkenylated heteroaromatics can be accessed by simple Brønsted acid catalysed union of diverse heteroarene N-oxides with alkenes. The approach is notable because (a) it is operationally simple, (b) the Brønsted acid catalyst is cheap, non-toxic and sustainable, (c) the N-oxide activator disappears during the reaction, and (d) water is the sole stoichiometric byproduct of the process. The new protocol offers orthogonal functional group tolerance to metal-catalysed methods and can be integrated easily into synthetic sequences to provide polyfunctionalised targets. In broader terms, this study demonstrates how classical organic reactivity can still be used to provide solutions to contemporary synthetic challenges that might otherwise be approached using transition metal catalysis.
Original languageEnglish
Pages (from-to)5820-5825
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number24
Early online date3 May 2016
DOIs
Publication statusPublished - 28 Jun 2016

Structured keywords

  • BCS and TECS CDTs

Fingerprint Dive into the research topics of 'C2-Alkenylation of N-heteroaromatic compounds: Via Brønsted acid catalysis'. Together they form a unique fingerprint.

Cite this