C(5) Site-Selective Functionalization of (S)-Cotinine

Hugo Rego Campello; Timothy Gallagher

doi:10.1021/acs.joc.7b02704

C(5) Site-Selective Functionalization of (S)-Cotinine

Hugo Rego Campello
, Timothy Gallagher^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

1 Citation (Scopus)

398 Downloads (Pure)

Abstract

(S)-(-)-Cotinine 2 undergoes direct and site-selective iridium-catalyzed borylation to provide boronate ester 3 and bromide 4 which offer flexible entry to a range of C(5)-substituted cotinine variants.

Original language	English
Pages (from-to)	516-520
Number of pages	5
Journal	Journal of Organic Chemistry
Volume	83
Issue number	1
Early online date	5 Dec 2017
DOIs	https://doi.org/10.1021/acs.joc.7b02704
Publication status	Published - 5 Jan 2018

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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via ACS at http://pubs.acs.org/doi/10.1021/acs.joc.7b02704 . Please refer to any applicable terms of use of the publisher.
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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via ACS at http://pubs.acs.org/doi/10.1021/acs.joc.7b02704 . Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 957 KB

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@article{cf07faa45de14bdab5faff89222ac1c9,

title = "C(5) Site-Selective Functionalization of (S)-Cotinine",

abstract = "(S)-(-)-Cotinine 2 undergoes direct and site-selective iridium-catalyzed borylation to provide boronate ester 3 and bromide 4 which offer flexible entry to a range of C(5)-substituted cotinine variants.",

author = "\{Rego Campello\}, Hugo and Timothy Gallagher",

year = "2018",

month = jan,

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doi = "10.1021/acs.joc.7b02704",

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volume = "83",

pages = "516--520",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

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T1 - C(5) Site-Selective Functionalization of (S)-Cotinine

AU - Rego Campello, Hugo

AU - Gallagher, Timothy

PY - 2018/1/5

Y1 - 2018/1/5

N2 - (S)-(-)-Cotinine 2 undergoes direct and site-selective iridium-catalyzed borylation to provide boronate ester 3 and bromide 4 which offer flexible entry to a range of C(5)-substituted cotinine variants.

AB - (S)-(-)-Cotinine 2 undergoes direct and site-selective iridium-catalyzed borylation to provide boronate ester 3 and bromide 4 which offer flexible entry to a range of C(5)-substituted cotinine variants.

UR - https://www.scopus.com/pages/publications/85042041150

U2 - 10.1021/acs.joc.7b02704

DO - 10.1021/acs.joc.7b02704

M3 - Article (Academic Journal)

C2 - 29207240

AN - SCOPUS:85042041150

SN - 0022-3263

VL - 83

SP - 516

EP - 520

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 1

ER -

C(5) Site-Selective Functionalization of (S)-Cotinine

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Nicotinic Ligand Development to Target Smoking Cessation and Gain a Molecular Level Understanding of Partial Agonism

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C(5) Site-Selective Functionalization of (S)-Cotinine

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Nicotinic Ligand Development to Target Smoking Cessation and Gain a Molecular Level Understanding of Partial Agonism

Cite this