Cage-induced stereotypic behaviour in laboratory mice covaries with nucleus accumbens FosB/ΔFosB expression

Danielle Philips, Elena Choleris, Kelsy Ervin, Carole Fureix, Laura Harper, Kathryn Reynolds, Lee Niel, Georgia Mason

Research output: Contribution to journalArticle (Academic Journal)peer-review

6 Citations (Scopus)
260 Downloads (Pure)

Abstract

Stereotypic behaviour (SB) occurs in certain human disorders (e.g. autism), and animals treated with stimulants or raised in impoverished conditions, including laboratory mice in standard cages. Dysfunctional cortico-basal ganglia pathways have been implicated in these examples, but for cage-induced forms of SB, the relative roles of ventral versus dorsal striatum had not been fully ascertained. Here, we used immunohistochemical staining of FosB and ΔFosB to assess long-term activation within the nucleus accumbens and caudate-putamen of C57BL/6 mice. Housed in typical laboratory cages, these mice spontaneously developed different degrees of route-tracing, bar-mouthing and other forms of SB (spending 0% to over 50% of their active time budgets in this behaviour). The most highly stereotypic mice showed the most elevated FosB/ΔFosB activity in the nucleus accumbens. No such patterns occurred in the caudate-putamen. The cage-induced SB common in standard-housed mice thus involves elevated activity within the ventral striatum, suggesting an aetiology closer to compulsive gambling, eating and drug-seeking than to classic amphetamine stereotypies and other behaviours induced by motor loop over-activation.
Original languageEnglish
Pages (from-to)238-242
Number of pages5
JournalBehavioural Brain Research
Volume301
Early online date28 Dec 2015
DOIs
Publication statusPublished - 15 Mar 2016

Keywords

  • Stereotypic behaviour
  • Stereotypy
  • Abnormal repetitive behaviour
  • Nucleus accumbens
  • Caudate-putamen
  • Striatum
  • Transcription factor
  • ΔFosB

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