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Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus

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Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus. / Park, Pojeong; Sanderson, Tom; Amici, Mascia; Choi, Sun-Lim; Bortolotto, Zuner; Zhuo, M; Kaang, BK; Collingridge, Graham.

In: Journal of Neuroscience, Vol. 36, No. 2, 13.01.2016, p. 622-631.

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Park, Pojeong ; Sanderson, Tom ; Amici, Mascia ; Choi, Sun-Lim ; Bortolotto, Zuner ; Zhuo, M ; Kaang, BK ; Collingridge, Graham. / Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus. In: Journal of Neuroscience. 2016 ; Vol. 36, No. 2. pp. 622-631.

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@article{1872446c82f448179c3b781e6edd7eb0,
title = "Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus",
abstract = "Two forms of NMDA receptor (NMDAR) dependent long-term potentiation (LTP) at hippocampal CA1 synapses can be distinguished based on their sensitivity to inhibitors of protein kinase A (PKA). The PKA-dependent form requires multiple episodes of high frequency stimulation (HFS) or theta burst stimuli (TBS) with a spacing between episodes in the order of minutes. To investigate the mechanism by which spaced episodes induce the PKA-dependent form of LTP we have compared, in interleaved experiments, spaced (s) and compressed (c) TBS protocols in the rat CA1 synapses. We find that LTP induced by sTBS, but not that induced by cTBS, involves the insertion of calcium-permeable (CP) AMPARs, as assessed using pharmacological and electrophysiological criteria. Furthermore, a single TBS when paired with rolipram, to activate PKA, generates an LTP that also involves the insertion of CP-AMPARs. These data demonstrate that the involvement of CP-AMPARs in LTP is critically determined by the timing of the induction trigger and is specifically associated with the PKA-dependent form of LTP.",
keywords = "calcium-permeable AMPA receptor, hippocampus, long-term potentiation, NMDA receptor, PKA, rectification",
author = "Pojeong Park and Tom Sanderson and Mascia Amici and Sun-Lim Choi and Zuner Bortolotto and M Zhuo and BK Kaang and Graham Collingridge",
year = "2016",
month = "1",
day = "13",
doi = "10.1523/JNEUROSCI.3625-15.2016",
language = "English",
volume = "36",
pages = "622--631",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "2",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus

AU - Park, Pojeong

AU - Sanderson, Tom

AU - Amici, Mascia

AU - Choi, Sun-Lim

AU - Bortolotto, Zuner

AU - Zhuo, M

AU - Kaang, BK

AU - Collingridge, Graham

PY - 2016/1/13

Y1 - 2016/1/13

N2 - Two forms of NMDA receptor (NMDAR) dependent long-term potentiation (LTP) at hippocampal CA1 synapses can be distinguished based on their sensitivity to inhibitors of protein kinase A (PKA). The PKA-dependent form requires multiple episodes of high frequency stimulation (HFS) or theta burst stimuli (TBS) with a spacing between episodes in the order of minutes. To investigate the mechanism by which spaced episodes induce the PKA-dependent form of LTP we have compared, in interleaved experiments, spaced (s) and compressed (c) TBS protocols in the rat CA1 synapses. We find that LTP induced by sTBS, but not that induced by cTBS, involves the insertion of calcium-permeable (CP) AMPARs, as assessed using pharmacological and electrophysiological criteria. Furthermore, a single TBS when paired with rolipram, to activate PKA, generates an LTP that also involves the insertion of CP-AMPARs. These data demonstrate that the involvement of CP-AMPARs in LTP is critically determined by the timing of the induction trigger and is specifically associated with the PKA-dependent form of LTP.

AB - Two forms of NMDA receptor (NMDAR) dependent long-term potentiation (LTP) at hippocampal CA1 synapses can be distinguished based on their sensitivity to inhibitors of protein kinase A (PKA). The PKA-dependent form requires multiple episodes of high frequency stimulation (HFS) or theta burst stimuli (TBS) with a spacing between episodes in the order of minutes. To investigate the mechanism by which spaced episodes induce the PKA-dependent form of LTP we have compared, in interleaved experiments, spaced (s) and compressed (c) TBS protocols in the rat CA1 synapses. We find that LTP induced by sTBS, but not that induced by cTBS, involves the insertion of calcium-permeable (CP) AMPARs, as assessed using pharmacological and electrophysiological criteria. Furthermore, a single TBS when paired with rolipram, to activate PKA, generates an LTP that also involves the insertion of CP-AMPARs. These data demonstrate that the involvement of CP-AMPARs in LTP is critically determined by the timing of the induction trigger and is specifically associated with the PKA-dependent form of LTP.

KW - calcium-permeable AMPA receptor

KW - hippocampus

KW - long-term potentiation

KW - NMDA receptor

KW - PKA

KW - rectification

U2 - 10.1523/JNEUROSCI.3625-15.2016

DO - 10.1523/JNEUROSCI.3625-15.2016

M3 - Article

C2 - 26758849

VL - 36

SP - 622

EP - 631

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 2

ER -