Campylobacter jejuni gene expression in the chick cecum: evidence for adaptation to a low-oxygen environment

C A Woodall, M A Jones, P A Barrow, J Hinds, G L Marsden, D J Kelly, N Dorrell, B W Wren, D J Maskell

Research output: Contribution to journalArticle (Academic Journal)

Abstract

Transcriptional profiling of Campylobacter jejuni during colonization of the chick cecum identified 59 genes that were differentially expressed in vivo compared with the genes in vitro. The data suggest that C. jejuni regulates electron transport and central metabolic pathways to alter its physiological state during establishment in the chick cecum.

Original languageEnglish
Pages (from-to)5278-85
Number of pages8
JournalInfection and Immunity
Volume73
Issue number8
DOIs
Publication statusPublished - 10 Aug 2005

Keywords

  • Adaptation, Physiological
  • Animals
  • Campylobacter Infections/metabolism
  • Campylobacter jejuni/genetics
  • Cecum/microbiology
  • Chickens/microbiology
  • Electron Transport
  • Gene Expression/physiology
  • Gene Expression Profiling
  • Oligonucleotide Array Sequence Analysis
  • Oxygen/metabolism

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