Cancer and the bromodomains of BAF180

Peter M Brownlee; Anna L Chambers; Antony W Oliver; Jessica A Downs

doi:10.1042/BST20110754

Cancer and the bromodomains of BAF180

Peter M Brownlee, Anna L Chambers, Antony W Oliver, Jessica A Downs

Research output: Contribution to journal › Article (Academic Journal)

27 Citations (Scopus)

Abstract

Chromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-templated activities, including regulation of gene expression and DNA repair. Mutations in subunits of the PBAF (polybromo/Brg1-associated factor) or SWI/SNF-B remodelling complex, including BAF180, are frequently associated with cancer. There are six potential acetyl-lysine-binding BDs (bromodomains) in BAF180, which may function to target the PBAF complex to promoters or sites of DNA repair. In the present review, we discuss what is currently known about the BDs of BAF180 and their potential significance in cancer.

Original language	English
Pages (from-to)	364-9
Number of pages	6
Journal	Biochemical Society Transactions
Volume	40
Issue number	2
DOIs	https://doi.org/10.1042/BST20110754
Publication status	Published - Apr 2012

Keywords

Animals
Humans
Mutation
Neoplasms
Nuclear Proteins
Protein Binding
Protein Structure, Tertiary
Protein Subunits

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Cancer and the bromodomains of BAF180",

abstract = "Chromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-templated activities, including regulation of gene expression and DNA repair. Mutations in subunits of the PBAF (polybromo/Brg1-associated factor) or SWI/SNF-B remodelling complex, including BAF180, are frequently associated with cancer. There are six potential acetyl-lysine-binding BDs (bromodomains) in BAF180, which may function to target the PBAF complex to promoters or sites of DNA repair. In the present review, we discuss what is currently known about the BDs of BAF180 and their potential significance in cancer.",

keywords = "Animals, Humans, Mutation, Neoplasms, Nuclear Proteins, Protein Binding, Protein Structure, Tertiary, Protein Subunits",

author = "Brownlee, {Peter M} and Chambers, {Anna L} and Oliver, {Antony W} and Downs, {Jessica A}",

year = "2012",

month = apr,

doi = "10.1042/BST20110754",

language = "English",

volume = "40",

pages = "364--9",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

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TY - JOUR

T1 - Cancer and the bromodomains of BAF180

AU - Brownlee, Peter M

AU - Chambers, Anna L

AU - Oliver, Antony W

AU - Downs, Jessica A

PY - 2012/4

Y1 - 2012/4

N2 - Chromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-templated activities, including regulation of gene expression and DNA repair. Mutations in subunits of the PBAF (polybromo/Brg1-associated factor) or SWI/SNF-B remodelling complex, including BAF180, are frequently associated with cancer. There are six potential acetyl-lysine-binding BDs (bromodomains) in BAF180, which may function to target the PBAF complex to promoters or sites of DNA repair. In the present review, we discuss what is currently known about the BDs of BAF180 and their potential significance in cancer.

AB - Chromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-templated activities, including regulation of gene expression and DNA repair. Mutations in subunits of the PBAF (polybromo/Brg1-associated factor) or SWI/SNF-B remodelling complex, including BAF180, are frequently associated with cancer. There are six potential acetyl-lysine-binding BDs (bromodomains) in BAF180, which may function to target the PBAF complex to promoters or sites of DNA repair. In the present review, we discuss what is currently known about the BDs of BAF180 and their potential significance in cancer.

KW - Animals

KW - Humans

KW - Mutation

KW - Neoplasms

KW - Nuclear Proteins

KW - Protein Binding

KW - Protein Structure, Tertiary

KW - Protein Subunits

U2 - 10.1042/BST20110754

DO - 10.1042/BST20110754

M3 - Article (Academic Journal)

C2 - 22435813

SN - 0300-5127

VL - 40

SP - 364

EP - 369

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 2

ER -

Cancer and the bromodomains of BAF180

Abstract

Keywords

UN SDGs

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