Cancer and the bromodomains of BAF180

Peter M Brownlee, Anna L Chambers, Antony W Oliver, Jessica A Downs

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)

Abstract

Chromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-templated activities, including regulation of gene expression and DNA repair. Mutations in subunits of the PBAF (polybromo/Brg1-associated factor) or SWI/SNF-B remodelling complex, including BAF180, are frequently associated with cancer. There are six potential acetyl-lysine-binding BDs (bromodomains) in BAF180, which may function to target the PBAF complex to promoters or sites of DNA repair. In the present review, we discuss what is currently known about the BDs of BAF180 and their potential significance in cancer.

Original languageEnglish
Pages (from-to)364-9
Number of pages6
JournalBiochemical Society Transactions
Volume40
Issue number2
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Animals
  • Humans
  • Mutation
  • Neoplasms
  • Nuclear Proteins
  • Protein Binding
  • Protein Structure, Tertiary
  • Protein Subunits

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