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Rhodacyclopentanones derived from carbonylative C-C activation of cyclopropyl ureas can be “captured” by pendant nucleophiles prior to “collapse” to 1,3-diazepanes. The choice of N-substituent on the cyclopropane unit controls the oxidation level of the product, such that C4-C5 unsaturated or saturated systems can be accessed selectively. The results outlined here validate a potentially general approach to medium-ring heterocycles
- BCS and TECS CDTs
FingerprintDive into the research topics of 'Capture–Collapse Heterocyclization: 1,3-Diazepanes by C–N Reductive Elimination from Rhodacyclopentanones'. Together they form a unique fingerprint.
- 2 Finished
28/02/14 → 29/11/17