Carbon-based glyco-nanoplatforms: towards the next generation of glycan-based multivalent probes

Javier Ramos-Soriano, Mattia Ghirardello, M Carmen Galan*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

8 Citations (Scopus)

Abstract

Cell surface carbohydrates mediate a wide range of carbohydrate-protein interactions key to healthy and disease mechanisms. Many of such interactions are multivalent in nature and in order to study these processes at a molecular level, many glycan-presenting platforms have been developed over the years. Among those, carbon nanoforms such as graphene and their derivatives, carbon nanotubes, carbon dots and fullerenes, have become very attractive as biocompatible platforms that can mimic the multivalent presentation of biologically relevant glycosides. The most recent examples of carbon-based nanoplatforms and their applications developed over the last few years to study carbohydrate-mediate interactions in the context of cancer, bacterial and viral infections, among others, are highlighted in this review.

Original languageEnglish
Pages (from-to)9960-9985
Number of pages26
JournalChemical Society Reviews
Volume51
Issue number24
Early online date23 Nov 2022
DOIs
Publication statusE-pub ahead of print - 23 Nov 2022

Keywords

  • Nanotubes, Carbon
  • Polysaccharides
  • Carbohydrates
  • Glycosides

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