Carbon monoxide: toxic molecule with antiinflammatory and cytoprotective properties

P Schober, A Koch, KD Zacharowski, SA Loer

    Research output: Contribution to journalArticle (Academic Journal)peer-review

    4 Citations (Scopus)

    Abstract

    Carbon monoxide arises during incomplete combustion of organic material, is incorporated into the circulation via the lungs and displaces oxygen from hemoglobin. Consecutively, symptoms of intoxication such as headache, vertigo, nausea, seizures and coma may result in a dose dependent fashion. Carbon monoxide is however also generated endogenously during heme degradation catalysed by heme oxgenase enzymes. The isoform hemeoxygenase-1 is inducible by oxidative stress and may mediate cytoprotection mainly attributable to endogenously produced carbon monoxide. Exogenous applied carbon monoxide has also been shown to confer protection in experimental studies. Meanwhile, in addition to the toxicological properties, antiinflammatory and cytoprotective effects of carbon monoxide have moved into the focus of scientific interest.
    Translated title of the contributionCarbon monoxide: toxic molecule with antiinflammatory and cytoprotective properties
    Original languageEnglish
    Pages (from-to)140 - 149
    Number of pages10
    JournalAnästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie
    Volume41 (3)
    DOIs
    Publication statusPublished - Mar 2006

    Bibliographical note

    Publisher: Thieme

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