TY - JOUR
T1 - Carbon quantum dot coated Fe
3
O
4
hybrid composites for sensitive electrochemical detection of uric acid
AU - Abbas, Malik Waseem
AU - Soomro, Razium Ali
AU - Kalwar, Nazar Hussain
AU - Zahoor, Mehvish
AU - Avci, Ahmet
AU - Pehlivan, Erol
AU - Hallam, Keith Richard
AU - Willander, Magnus
PY - 2019/5/1
Y1 - 2019/5/1
N2 -
The study explores carbon quantum dots (C-dots) as potential candidates for enhancing the signal sensitivity of an electrochemical sensor devised for biologically important molecule, such as uric acid (UA). The C-dots were evaluated for their electrochemical characteristics in combination with Fe
3
O
4
nanoparticles (Fe
3
O
4
NPs), which were applied as the primary electro-catalytic promoter. The hybrid nanocomposite (C-dots/Fe
3
O
4
HCs) formation was achieved by facilitating the adsorption of C-dots over Fe
3
O
4
NPs using amine-carbonyl interactions. Unlike, one pot method, the proposed strategy enables aggregation-free coverage of Fe
3
O
4
NPs with highly conductive layer of C-dots that can act as conduction centres to support ultra-fast electron transfer kinetics to satisfy the need of high signal sensitivity. The hybrid composite demonstrated remarkable signal improvement when tested against the electrochemical oxidation of UA. The heighten current response and lower over-potential values enabled development of a DC-amperometric (DC-AMP) sensor for UA with a linear working range of 0.01 to 0.145 μM and signal sensitivity measurable up to 6.0 × 10
−9
M. The said improvement was manifested as a synergetic outcome of active redox couple (Fe (III/II)), larger surface area of Fe
3
O
4
NPs engulfed with a layer of highly conductive C-dots acting as efficient charge sensitisers.
AB -
The study explores carbon quantum dots (C-dots) as potential candidates for enhancing the signal sensitivity of an electrochemical sensor devised for biologically important molecule, such as uric acid (UA). The C-dots were evaluated for their electrochemical characteristics in combination with Fe
3
O
4
nanoparticles (Fe
3
O
4
NPs), which were applied as the primary electro-catalytic promoter. The hybrid nanocomposite (C-dots/Fe
3
O
4
HCs) formation was achieved by facilitating the adsorption of C-dots over Fe
3
O
4
NPs using amine-carbonyl interactions. Unlike, one pot method, the proposed strategy enables aggregation-free coverage of Fe
3
O
4
NPs with highly conductive layer of C-dots that can act as conduction centres to support ultra-fast electron transfer kinetics to satisfy the need of high signal sensitivity. The hybrid composite demonstrated remarkable signal improvement when tested against the electrochemical oxidation of UA. The heighten current response and lower over-potential values enabled development of a DC-amperometric (DC-AMP) sensor for UA with a linear working range of 0.01 to 0.145 μM and signal sensitivity measurable up to 6.0 × 10
−9
M. The said improvement was manifested as a synergetic outcome of active redox couple (Fe (III/II)), larger surface area of Fe
3
O
4
NPs engulfed with a layer of highly conductive C-dots acting as efficient charge sensitisers.
KW - C-dots
KW - Electrochemical sensors
KW - Magnetite NPs
KW - Uric acid
UR - http://www.scopus.com/inward/record.url?scp=85060330277&partnerID=8YFLogxK
U2 - 10.1016/j.microc.2019.01.034
DO - 10.1016/j.microc.2019.01.034
M3 - Article (Academic Journal)
AN - SCOPUS:85060330277
VL - 146
SP - 517
EP - 524
JO - Microchemical Journal
JF - Microchemical Journal
SN - 0026-265X
ER -