Carbonylative C-C Bond Activation of Electron-Poor Cyclopropanes: Rhodium‐Catalyzed (3+1+2) Cycloadditions of Cyclopropylamides

Andrew Dalling, Takayuki Yamauchi, Niall McCreanor, Lydia Cox, John Bower*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)
131 Downloads (Pure)

Abstract

Rh‐catalyzed carbonylative C−C bond activation of cyclopropylamides generates configurationally stable rhodacyclopentanones that engage tethered alkenes in (3+1+2) cycloadditions. These studies provide the first examples of multicomponent cycloadditions that proceed through C−C bond activation of “simple” electron poor cyclopropanes.
Original languageEnglish
Pages (from-to)221-225
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number1
Early online date29 Nov 2018
DOIs
Publication statusPublished - 2 Jan 2019

Structured keywords

  • BCS and TECS CDTs

Keywords

  • C−C activation
  • cycloaddition
  • cyclopropane
  • rhodium

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