Carbonylative C–C Bond Activation of Aminocyclopropanes Using a Temporary Directing Group Strategy

Gang-Wei Wang, Olga O. Sokolova, Tom A. Young, Ektor M. S. Christodoulou, Craig P. Butts, John F. Bower*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Temporary directing groups (TDGs) underpin a range of C–C bond activation methodologies; however, the use of TDGs for the regiocontrolled activation of cyclopropane C–C bonds is underdeveloped. In this report, we show how an unusual ring contraction process can be harnessed for TDG-based carbonylative C–C bond activations of cyclopropanes. The method involves the transient installation of an isocyanate-derived TDG, rather than relying on carbonyl condensation events as used in previous TDG-enabled C–C bond activations.
Original languageEnglish
Pages (from-to)19006–19011
Number of pages6
JournalJournal of the American Chemical Society
Volume142
Issue number45
Early online date30 Oct 2020
DOIs
Publication statusPublished - 11 Nov 2020

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