Carcinoma cuniculatum arising in the tongue

Selvam Thavaraj, Alistair Cobb, Nicholas Kalavrezos, Timothy Beale, Donald Murray Walker, Amrita Jay

Research output: Contribution to journalArticle (Academic Journal)peer-review

25 Citations (Scopus)


Carcinoma cuniculatum (CC) is a rare, distinct clinico-pathological variant of squamous cell carcinoma (SCC) that is defined histologically by the characteristic infiltrative pattern of a deep, broad, and complex proliferation of stratified squamous epithelium with keratin cores and keratin-filled crypts. Herein, we present a case report of CC of the oral tongue and discuss its diagnosis, management, and outcome, as well as briefly review the world literature. To our knowledge, this is the first documented case of CC of the tongue to be reported in the English literature. We draw attention to its clinico-pathological features and highlight that awareness of this entity as a distinct variant of SCC facilitates its correct management.

Original languageEnglish
Pages (from-to)130-4
Number of pages5
JournalHead and Neck Pathology
Issue number1
Publication statusPublished - Mar 2012


  • Carcinoma, Squamous Cell
  • Carcinoma, Verrucous
  • Humans
  • Male
  • Middle Aged
  • Tongue
  • Tongue Neoplasms


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