Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin

Pankaj Garg, Paul Morris, Asma Lina Fazlanie, Sethumadhavan Vijayan, Balazs Dancso, Amardeep Ghosh Dastidar, Sven Plein, Christian Mueller, Philip Haaf

Research output: Contribution to journalReview article (Academic Journal)peer-review

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Abstract

The role of cardiac troponins as diagnostic biomarkers of myocardial injury in the context of acute coronary syndrome (ACS) is well established. Since the initial 1st-generation assays, 5th-generation high-sensitivity cardiac troponin (hs-cTn) assays have been developed, and are now widely used. However, its clinical adoption preceded guidelines and even best practice evidence. This review summarizes the history of cardiac biomarkers with particular emphasis on hs-cTn. We aim to provide insights into using hs-cTn as a quantitative marker of cardiomyocyte injury to help in the differential diagnosis of coronary versus non-coronary cardiac diseases. We also review the recent evidence and guidelines of using hs-cTn in suspected ACS.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalInternal and emergency medicine
Volume12
Issue number2
Early online date11 Feb 2017
DOIs
Publication statusPublished - Mar 2017

Keywords

  • Acute Coronary Syndrome
  • Biological Assay
  • Biomarkers
  • Early Diagnosis
  • Humans
  • Primary Prevention
  • Troponin
  • Journal Article
  • Review

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