Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin

Pankaj Garg; Paul Morris; Asma Lina Fazlanie; Sethumadhavan Vijayan; Balazs Dancso; Amardeep Ghosh Dastidar; Sven Plein; Christian Mueller; Philip Haaf

doi:10.1007/s11739-017-1612-1

Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin

Pankaj Garg, Paul Morris, Asma Lina Fazlanie, Sethumadhavan Vijayan, Balazs Dancso, Amardeep Ghosh Dastidar, Sven Plein, Christian Mueller, Philip Haaf

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Abstract

The role of cardiac troponins as diagnostic biomarkers of myocardial injury in the context of acute coronary syndrome (ACS) is well established. Since the initial 1st-generation assays, 5th-generation high-sensitivity cardiac troponin (hs-cTn) assays have been developed, and are now widely used. However, its clinical adoption preceded guidelines and even best practice evidence. This review summarizes the history of cardiac biomarkers with particular emphasis on hs-cTn. We aim to provide insights into using hs-cTn as a quantitative marker of cardiomyocyte injury to help in the differential diagnosis of coronary versus non-coronary cardiac diseases. We also review the recent evidence and guidelines of using hs-cTn in suspected ACS.

Original language	English
Pages (from-to)	147-155
Number of pages	9
Journal	Internal and emergency medicine
Volume	12
Issue number	2
Early online date	11 Feb 2017
DOIs	https://doi.org/10.1007/s11739-017-1612-1
Publication status	Published - Mar 2017

Keywords

Acute Coronary Syndrome
Biological Assay
Biomarkers
Early Diagnosis
Humans
Primary Prevention
Troponin
Journal Article
Review

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title = "Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin",

abstract = "The role of cardiac troponins as diagnostic biomarkers of myocardial injury in the context of acute coronary syndrome (ACS) is well established. Since the initial 1st-generation assays, 5th-generation high-sensitivity cardiac troponin (hs-cTn) assays have been developed, and are now widely used. However, its clinical adoption preceded guidelines and even best practice evidence. This review summarizes the history of cardiac biomarkers with particular emphasis on hs-cTn. We aim to provide insights into using hs-cTn as a quantitative marker of cardiomyocyte injury to help in the differential diagnosis of coronary versus non-coronary cardiac diseases. We also review the recent evidence and guidelines of using hs-cTn in suspected ACS.",

keywords = "Acute Coronary Syndrome, Biological Assay, Biomarkers, Early Diagnosis, Humans, Primary Prevention, Troponin, Journal Article, Review",

author = "Pankaj Garg and Paul Morris and Fazlanie, {Asma Lina} and Sethumadhavan Vijayan and Balazs Dancso and Dastidar, {Amardeep Ghosh} and Sven Plein and Christian Mueller and Philip Haaf",

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T2 - from history to high-sensitivity cardiac troponin

AU - Garg, Pankaj

AU - Morris, Paul

AU - Fazlanie, Asma Lina

AU - Vijayan, Sethumadhavan

AU - Dancso, Balazs

AU - Dastidar, Amardeep Ghosh

AU - Plein, Sven

AU - Mueller, Christian

AU - Haaf, Philip

PY - 2017/3

Y1 - 2017/3

N2 - The role of cardiac troponins as diagnostic biomarkers of myocardial injury in the context of acute coronary syndrome (ACS) is well established. Since the initial 1st-generation assays, 5th-generation high-sensitivity cardiac troponin (hs-cTn) assays have been developed, and are now widely used. However, its clinical adoption preceded guidelines and even best practice evidence. This review summarizes the history of cardiac biomarkers with particular emphasis on hs-cTn. We aim to provide insights into using hs-cTn as a quantitative marker of cardiomyocyte injury to help in the differential diagnosis of coronary versus non-coronary cardiac diseases. We also review the recent evidence and guidelines of using hs-cTn in suspected ACS.

AB - The role of cardiac troponins as diagnostic biomarkers of myocardial injury in the context of acute coronary syndrome (ACS) is well established. Since the initial 1st-generation assays, 5th-generation high-sensitivity cardiac troponin (hs-cTn) assays have been developed, and are now widely used. However, its clinical adoption preceded guidelines and even best practice evidence. This review summarizes the history of cardiac biomarkers with particular emphasis on hs-cTn. We aim to provide insights into using hs-cTn as a quantitative marker of cardiomyocyte injury to help in the differential diagnosis of coronary versus non-coronary cardiac diseases. We also review the recent evidence and guidelines of using hs-cTn in suspected ACS.

KW - Acute Coronary Syndrome

KW - Biological Assay

KW - Biomarkers

KW - Early Diagnosis

KW - Humans

KW - Primary Prevention

KW - Troponin

KW - Journal Article

KW - Review

U2 - 10.1007/s11739-017-1612-1

DO - 10.1007/s11739-017-1612-1

M3 - Review article (Academic Journal)

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SN - 1828-0447

VL - 12

SP - 147

EP - 155

JO - Internal and emergency medicine

JF - Internal and emergency medicine

IS - 2

ER -

Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin

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