Cardiovascular biomarkers and vascular function during childhood in the offspring of mothers with hypertensive disorders of pregnancy: findings from the Avon Longitudinal Study of Parents and Children

Debbie Anne Lawlor; Corrie Macdonald-Wallis; Abigail Fraser; Scott M Nelson; Aroon Hingorani; George Davey Smith; Naveed Sattar; John Deanfield

doi:10.1093/eurheartj/ehr300

Cardiovascular biomarkers and vascular function during childhood in the offspring of mothers with hypertensive disorders of pregnancy: findings from the Avon Longitudinal Study of Parents and Children

Debbie Anne Lawlor, Corrie Macdonald-Wallis, Abigail Fraser, Scott M Nelson, Aroon Hingorani, George Davey Smith, Naveed Sattar, John Deanfield

Research output: Contribution to journal › Article (Academic Journal) › peer-review

127 Citations (Scopus)

Abstract

It is uncertain if the higher blood pressure (BP) observed in the offspring of hypertensive pregnancies is an isolated abnormality or one that is accompanied by impaired vascular function and alterations in lipid and inflammation markers that would be indicative of a more general cardiometabolic disturbance of the type observed in the mother during pre-eclampsia.

Original language	English
Pages (from-to)	335-45
Number of pages	11
Journal	European Heart Journal
Volume	33
Issue number	3
DOIs	https://doi.org/10.1093/eurheartj/ehr300
Publication status	Published - Feb 2012

Keywords

Blood Pressure
Humans
Vascular Diseases
Child
Longitudinal Studies
Endothelium, Vascular
Pregnancy
Hypertension, Pregnancy-Induced
Prospective Studies
Adult
Ankle Brachial Index
Biological Markers
Female
Lipid Metabolism

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10.1093/eurheartj/ehr300

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MRC TRAINING FELLOWSHIP FOR A FRASER: OBSTETRIC, LIFESTYLE & GENETIC DETERMINANTS OF VASCULAR METABLIC TRAITS
Lawlor, D. A. (Principal Investigator)
1/09/08 → 1/09/14
Project: Research
CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)
Davey Smith, G. (Principal Investigator)
1/09/07 → 1/09/13
Project: Research

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Lawlor, D. A., Macdonald-Wallis, C., Fraser, A., Nelson, S. M., Hingorani, A., Davey Smith, G., Sattar, N., & Deanfield, J. (2012). Cardiovascular biomarkers and vascular function during childhood in the offspring of mothers with hypertensive disorders of pregnancy: findings from the Avon Longitudinal Study of Parents and Children. European Heart Journal, 33(3), 335-45. https://doi.org/10.1093/eurheartj/ehr300

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title = "Cardiovascular biomarkers and vascular function during childhood in the offspring of mothers with hypertensive disorders of pregnancy: findings from the Avon Longitudinal Study of Parents and Children",

abstract = "It is uncertain if the higher blood pressure (BP) observed in the offspring of hypertensive pregnancies is an isolated abnormality or one that is accompanied by impaired vascular function and alterations in lipid and inflammation markers that would be indicative of a more general cardiometabolic disturbance of the type observed in the mother during pre-eclampsia.",

keywords = "Blood Pressure, Humans, Vascular Diseases, Child, Longitudinal Studies, Endothelium, Vascular, Pregnancy, Hypertension, Pregnancy-Induced, Prospective Studies, Adult, Ankle Brachial Index, Biological Markers, Female, Lipid Metabolism",

author = "Lawlor, {Debbie Anne} and Corrie Macdonald-Wallis and Abigail Fraser and Nelson, {Scott M} and Aroon Hingorani and {Davey Smith}, George and Naveed Sattar and John Deanfield",

year = "2012",

month = feb,

doi = "10.1093/eurheartj/ehr300",

language = "English",

volume = "33",

pages = "335--45",

journal = "European Heart Journal",

issn = "1522-9645",

publisher = "Oxford University Press",

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Lawlor, DA, Macdonald-Wallis, C, Fraser, A, Nelson, SM, Hingorani, A, Davey Smith, G, Sattar, N & Deanfield, J 2012, 'Cardiovascular biomarkers and vascular function during childhood in the offspring of mothers with hypertensive disorders of pregnancy: findings from the Avon Longitudinal Study of Parents and Children', European Heart Journal, vol. 33, no. 3, pp. 335-45. https://doi.org/10.1093/eurheartj/ehr300

Cardiovascular biomarkers and vascular function during childhood in the offspring of mothers with hypertensive disorders of pregnancy: findings from the Avon Longitudinal Study of Parents and Children. / Lawlor, Debbie Anne; Macdonald-Wallis, Corrie; Fraser, Abigail et al.
In: European Heart Journal, Vol. 33, No. 3, 02.2012, p. 335-45.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Cardiovascular biomarkers and vascular function during childhood in the offspring of mothers with hypertensive disorders of pregnancy

T2 - findings from the Avon Longitudinal Study of Parents and Children

AU - Lawlor, Debbie Anne

AU - Macdonald-Wallis, Corrie

AU - Fraser, Abigail

AU - Nelson, Scott M

AU - Hingorani, Aroon

AU - Davey Smith, George

AU - Sattar, Naveed

AU - Deanfield, John

PY - 2012/2

Y1 - 2012/2

N2 - It is uncertain if the higher blood pressure (BP) observed in the offspring of hypertensive pregnancies is an isolated abnormality or one that is accompanied by impaired vascular function and alterations in lipid and inflammation markers that would be indicative of a more general cardiometabolic disturbance of the type observed in the mother during pre-eclampsia.

AB - It is uncertain if the higher blood pressure (BP) observed in the offspring of hypertensive pregnancies is an isolated abnormality or one that is accompanied by impaired vascular function and alterations in lipid and inflammation markers that would be indicative of a more general cardiometabolic disturbance of the type observed in the mother during pre-eclampsia.

KW - Blood Pressure

KW - Humans

KW - Vascular Diseases

KW - Child

KW - Longitudinal Studies

KW - Endothelium, Vascular

KW - Pregnancy

KW - Hypertension, Pregnancy-Induced

KW - Prospective Studies

KW - Adult

KW - Ankle Brachial Index

KW - Biological Markers

KW - Female

KW - Lipid Metabolism

U2 - 10.1093/eurheartj/ehr300

DO - 10.1093/eurheartj/ehr300

M3 - Article (Academic Journal)

C2 - 21862461

SN - 1522-9645

VL - 33

SP - 335

EP - 345

JO - European Heart Journal

JF - European Heart Journal

IS - 3

ER -

Cardiovascular biomarkers and vascular function during childhood in the offspring of mothers with hypertensive disorders of pregnancy: findings from the Avon Longitudinal Study of Parents and Children

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Keywords

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Projects

MRC TRAINING FELLOWSHIP FOR A FRASER: OBSTETRIC, LIFESTYLE & GENETIC DETERMINANTS OF VASCULAR METABLIC TRAITS

CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)

Cite this