Carotid atherosclerotic plaque matrix metalloproteinase-12-positive macrophage subpopulation predicts adverse outcome after endarterectomy

Vincent P W Scholtes, Jason L Johnson, Nicholas Jenkins, Graciela B Sala-Newby, Jean-Paul P M de Vries, Gert Jan de Borst, Dominique P V de Kleijn, Frans L Moll, Gerard Pasterkamp, Andrew C Newby

Research output: Contribution to journalArticle (Academic Journal)peer-review

39 Citations (Scopus)
556 Downloads (Pure)

Abstract

Matrix metalloproteinase-12 (MMP-12) promotes atherosclerosis in animal models. MMP-12 is expressed in only a subset of foam-cell macrophages (FCMs) in human plaques. We investigated whether the prevalence of this MMP-12-expressing subpopulation is a prognostic indicator of adverse outcome in patients after carotid endarterectomy (CEA).
Original languageEnglish
Article numbere001040
Number of pages12
JournalJournal of the American Heart Association
Volume1
Issue number6
DOIs
Publication statusPublished - Dec 2012

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