TY - JOUR
T1 - Carotid atherosclerotic plaque matrix metalloproteinase-12-positive macrophage subpopulation predicts adverse outcome after endarterectomy
AU - Scholtes, Vincent P W
AU - Johnson, Jason L
AU - Jenkins, Nicholas
AU - Sala-Newby, Graciela B
AU - de Vries, Jean-Paul P M
AU - de Borst, Gert Jan
AU - de Kleijn, Dominique P V
AU - Moll, Frans L
AU - Pasterkamp, Gerard
AU - Newby, Andrew C
PY - 2012/12
Y1 - 2012/12
N2 - Matrix metalloproteinase-12 (MMP-12) promotes atherosclerosis in animal models. MMP-12 is expressed in only a subset of foam-cell macrophages (FCMs) in human plaques. We investigated whether the prevalence of this MMP-12-expressing subpopulation is a prognostic indicator of adverse outcome in patients after carotid endarterectomy (CEA).
AB - Matrix metalloproteinase-12 (MMP-12) promotes atherosclerosis in animal models. MMP-12 is expressed in only a subset of foam-cell macrophages (FCMs) in human plaques. We investigated whether the prevalence of this MMP-12-expressing subpopulation is a prognostic indicator of adverse outcome in patients after carotid endarterectomy (CEA).
U2 - 10.1161/JAHA.112.001040
DO - 10.1161/JAHA.112.001040
M3 - Article (Academic Journal)
C2 - 23316311
SN - 2047-9980
VL - 1
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 6
M1 - e001040
ER -