Carotid atherosclerotic plaque matrix metalloproteinase-12-positive macrophage subpopulation predicts adverse outcome after endarterectomy

Vincent P W Scholtes; Jason L Johnson; Nicholas Jenkins; Graciela B Sala-Newby; Jean-Paul P M de Vries; Gert Jan de Borst; Dominique P V de Kleijn; Frans L Moll; Gerard Pasterkamp; Andrew C Newby

doi:10.1161/JAHA.112.001040

Carotid atherosclerotic plaque matrix metalloproteinase-12-positive macrophage subpopulation predicts adverse outcome after endarterectomy

Vincent P W Scholtes
, Jason L Johnson
, Nicholas Jenkins
, Graciela B Sala-Newby
, Jean-Paul P M de Vries
, Gert Jan de Borst
, Dominique P V de Kleijn
, Frans L Moll
, Gerard Pasterkamp
, Andrew C Newby

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

56 Citations (Scopus)

722 Downloads (Pure)

Abstract

Matrix metalloproteinase-12 (MMP-12) promotes atherosclerosis in animal models. MMP-12 is expressed in only a subset of foam-cell macrophages (FCMs) in human plaques. We investigated whether the prevalence of this MMP-12-expressing subpopulation is a prognostic indicator of adverse outcome in patients after carotid endarterectomy (CEA).

Original language	English
Article number	e001040
Number of pages	12
Journal	Journal of the American Heart Association
Volume	1
Issue number	6
DOIs	https://doi.org/10.1161/JAHA.112.001040
Publication status	Published - Dec 2012

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Carotid Atherosclerotic Plaque Matrix Metalloproteinase-12-Positive Macrophage Subpopulation Predicts Adverse Outcome After EndarterectomyFinal published version, 3.22 MB

http://jaha.ahajournals.org/content/1/6/e001040

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Scholtes, V. P. W., Johnson, J. L., Jenkins, N., Sala-Newby, G. B., de Vries, J.-P. P. M., de Borst, G. J., de Kleijn, D. P. V., Moll, F. L., Pasterkamp, G., & Newby, A. C. (2012). Carotid atherosclerotic plaque matrix metalloproteinase-12-positive macrophage subpopulation predicts adverse outcome after endarterectomy. Journal of the American Heart Association, 1(6), Article e001040. https://doi.org/10.1161/JAHA.112.001040

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title = "Carotid atherosclerotic plaque matrix metalloproteinase-12-positive macrophage subpopulation predicts adverse outcome after endarterectomy",

abstract = "Matrix metalloproteinase-12 (MMP-12) promotes atherosclerosis in animal models. MMP-12 is expressed in only a subset of foam-cell macrophages (FCMs) in human plaques. We investigated whether the prevalence of this MMP-12-expressing subpopulation is a prognostic indicator of adverse outcome in patients after carotid endarterectomy (CEA).",

author = "Scholtes, \{Vincent P W\} and Johnson, \{Jason L\} and Nicholas Jenkins and Sala-Newby, \{Graciela B\} and \{de Vries\}, \{Jean-Paul P M\} and \{de Borst\}, \{Gert Jan\} and \{de Kleijn\}, \{Dominique P V\} and Moll, \{Frans L\} and Gerard Pasterkamp and Newby, \{Andrew C\}",

year = "2012",

month = dec,

doi = "10.1161/JAHA.112.001040",

language = "English",

volume = "1",

journal = "Journal of the American Heart Association",

issn = "2047-9980",

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Scholtes, VPW, Johnson, JL, Jenkins, N, Sala-Newby, GB, de Vries, J-PPM, de Borst, GJ, de Kleijn, DPV, Moll, FL, Pasterkamp, G & Newby, AC 2012, 'Carotid atherosclerotic plaque matrix metalloproteinase-12-positive macrophage subpopulation predicts adverse outcome after endarterectomy', Journal of the American Heart Association, vol. 1, no. 6, e001040. https://doi.org/10.1161/JAHA.112.001040

Carotid atherosclerotic plaque matrix metalloproteinase-12-positive macrophage subpopulation predicts adverse outcome after endarterectomy. / Scholtes, Vincent P W; Johnson, Jason L; Jenkins, Nicholas et al.
In: Journal of the American Heart Association, Vol. 1, No. 6, e001040, 12.2012.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Carotid atherosclerotic plaque matrix metalloproteinase-12-positive macrophage subpopulation predicts adverse outcome after endarterectomy

AU - Scholtes, Vincent P W

AU - Johnson, Jason L

AU - Jenkins, Nicholas

AU - Sala-Newby, Graciela B

AU - de Vries, Jean-Paul P M

AU - de Borst, Gert Jan

AU - de Kleijn, Dominique P V

AU - Moll, Frans L

AU - Pasterkamp, Gerard

AU - Newby, Andrew C

PY - 2012/12

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N2 - Matrix metalloproteinase-12 (MMP-12) promotes atherosclerosis in animal models. MMP-12 is expressed in only a subset of foam-cell macrophages (FCMs) in human plaques. We investigated whether the prevalence of this MMP-12-expressing subpopulation is a prognostic indicator of adverse outcome in patients after carotid endarterectomy (CEA).

AB - Matrix metalloproteinase-12 (MMP-12) promotes atherosclerosis in animal models. MMP-12 is expressed in only a subset of foam-cell macrophages (FCMs) in human plaques. We investigated whether the prevalence of this MMP-12-expressing subpopulation is a prognostic indicator of adverse outcome in patients after carotid endarterectomy (CEA).

U2 - 10.1161/JAHA.112.001040

DO - 10.1161/JAHA.112.001040

M3 - Article (Academic Journal)

C2 - 23316311

SN - 2047-9980

VL - 1

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

IS - 6

M1 - e001040

ER -

Carotid atherosclerotic plaque matrix metalloproteinase-12-positive macrophage subpopulation predicts adverse outcome after endarterectomy

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