Carotid body removal for treatment of chronic systolic heart failure

Piotr Niewiński; Dariusz Janczak; Artur Rucinski; Przemyslaw Jazwiec; Paul A Sobotka; Zoar J Engelman; Marat Fudim; Stanislaw Tubek; Ewa A Jankowska; Waldemar Banasiak; Emma C J Hart; Julian F R Paton; Piotr Ponikowski

doi:10.1016/j.ijcard.2013.03.011

Carotid body removal for treatment of chronic systolic heart failure

Piotr Niewiński, Dariusz Janczak, Artur Rucinski, Przemyslaw Jazwiec, Paul A Sobotka, Zoar J Engelman, Marat Fudim, Stanislaw Tubek, Ewa A Jankowska, Waldemar Banasiak, Emma C J Hart, Julian F R Paton, Piotr Ponikowski

Research output: Contribution to journal › Article (Academic Journal) › peer-review

69 Citations (Scopus)

Abstract

BACKGROUND: Augmented reflex response from peripheral chemoreceptors characterises chronic heart failure (CHF), contributes to autonomic imbalance and exercise intolerance and predicts poor outcome.

METHODS AND RESULTS: We present a case of a 56-year-old male patient with ischaemic CHF, who underwent surgical, unilateral carotid body resection to reduce peripheral chemosensitivity. At 2-month and 6-month follow-ups, we document a persistent decrease in peripheral chemosensitivity accompanied by an improvement in exercise capacity, sleep disordered breathing and quality of life. Autonomic balance was favourably affected as evidenced by improved heart rate variability and augmented cardiac baroreflex sensitivity. There were no procedure-related adverse events.

CONCLUSIONS: Denervation of a carotid body may offer a clinical strategy to restore autonomic balance and improve morbidity in heart failure (NCT01653821).

Original language	English
Pages (from-to)	2506-9
Number of pages	4
Journal	International Journal of Cardiology
Volume	168
Issue number	3
DOIs	https://doi.org/10.1016/j.ijcard.2013.03.011
Publication status	Published - 3 Oct 2013

Bibliographical note

Keywords

Carotid Body
Chronic Disease
Heart Failure, Systolic
Humans
Male
Middle Aged

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10.1016/j.ijcard.2013.03.011

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Niewiński, Piotr ; Janczak, Dariusz ; Rucinski, Artur ; Jazwiec, Przemyslaw ; Sobotka, Paul A ; Engelman, Zoar J ; Fudim, Marat ; Tubek, Stanislaw ; Jankowska, Ewa A ; Banasiak, Waldemar ; Hart, Emma C J ; Paton, Julian F R ; Ponikowski, Piotr. / Carotid body removal for treatment of chronic systolic heart failure. In: International Journal of Cardiology. 2013 ; Vol. 168, No. 3. pp. 2506-9.

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abstract = "BACKGROUND: Augmented reflex response from peripheral chemoreceptors characterises chronic heart failure (CHF), contributes to autonomic imbalance and exercise intolerance and predicts poor outcome.METHODS AND RESULTS: We present a case of a 56-year-old male patient with ischaemic CHF, who underwent surgical, unilateral carotid body resection to reduce peripheral chemosensitivity. At 2-month and 6-month follow-ups, we document a persistent decrease in peripheral chemosensitivity accompanied by an improvement in exercise capacity, sleep disordered breathing and quality of life. Autonomic balance was favourably affected as evidenced by improved heart rate variability and augmented cardiac baroreflex sensitivity. There were no procedure-related adverse events.CONCLUSIONS: Denervation of a carotid body may offer a clinical strategy to restore autonomic balance and improve morbidity in heart failure (NCT01653821).",

keywords = "Carotid Body, Chronic Disease, Heart Failure, Systolic, Humans, Male, Middle Aged",

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Carotid body removal for treatment of chronic systolic heart failure. / Niewiński, Piotr; Janczak, Dariusz; Rucinski, Artur; Jazwiec, Przemyslaw; Sobotka, Paul A; Engelman, Zoar J; Fudim, Marat; Tubek, Stanislaw; Jankowska, Ewa A; Banasiak, Waldemar; Hart, Emma C J; Paton, Julian F R; Ponikowski, Piotr.

In: International Journal of Cardiology, Vol. 168, No. 3, 03.10.2013, p. 2506-9.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Carotid body removal for treatment of chronic systolic heart failure

AU - Niewiński, Piotr

AU - Janczak, Dariusz

AU - Rucinski, Artur

AU - Jazwiec, Przemyslaw

AU - Sobotka, Paul A

AU - Engelman, Zoar J

AU - Fudim, Marat

AU - Tubek, Stanislaw

AU - Jankowska, Ewa A

AU - Banasiak, Waldemar

AU - Hart, Emma C J

AU - Paton, Julian F R

AU - Ponikowski, Piotr

PY - 2013/10/3

Y1 - 2013/10/3

N2 - BACKGROUND: Augmented reflex response from peripheral chemoreceptors characterises chronic heart failure (CHF), contributes to autonomic imbalance and exercise intolerance and predicts poor outcome.METHODS AND RESULTS: We present a case of a 56-year-old male patient with ischaemic CHF, who underwent surgical, unilateral carotid body resection to reduce peripheral chemosensitivity. At 2-month and 6-month follow-ups, we document a persistent decrease in peripheral chemosensitivity accompanied by an improvement in exercise capacity, sleep disordered breathing and quality of life. Autonomic balance was favourably affected as evidenced by improved heart rate variability and augmented cardiac baroreflex sensitivity. There were no procedure-related adverse events.CONCLUSIONS: Denervation of a carotid body may offer a clinical strategy to restore autonomic balance and improve morbidity in heart failure (NCT01653821).

AB - BACKGROUND: Augmented reflex response from peripheral chemoreceptors characterises chronic heart failure (CHF), contributes to autonomic imbalance and exercise intolerance and predicts poor outcome.METHODS AND RESULTS: We present a case of a 56-year-old male patient with ischaemic CHF, who underwent surgical, unilateral carotid body resection to reduce peripheral chemosensitivity. At 2-month and 6-month follow-ups, we document a persistent decrease in peripheral chemosensitivity accompanied by an improvement in exercise capacity, sleep disordered breathing and quality of life. Autonomic balance was favourably affected as evidenced by improved heart rate variability and augmented cardiac baroreflex sensitivity. There were no procedure-related adverse events.CONCLUSIONS: Denervation of a carotid body may offer a clinical strategy to restore autonomic balance and improve morbidity in heart failure (NCT01653821).

KW - Carotid Body

KW - Chronic Disease

KW - Heart Failure, Systolic

KW - Humans

KW - Male

KW - Middle Aged

U2 - 10.1016/j.ijcard.2013.03.011

DO - 10.1016/j.ijcard.2013.03.011

M3 - Article (Academic Journal)

C2 - 23541331

VL - 168

SP - 2506

EP - 2509

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 3

ER -

Carotid body removal for treatment of chronic systolic heart failure

Abstract

Bibliographical note

Keywords

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