Carotid body removal for treatment of chronic systolic heart failure

Piotr Niewiński, Dariusz Janczak, Artur Rucinski, Przemyslaw Jazwiec, Paul A Sobotka, Zoar J Engelman, Marat Fudim, Stanislaw Tubek, Ewa A Jankowska, Waldemar Banasiak, Emma C J Hart, Julian F R Paton, Piotr Ponikowski

Research output: Contribution to journalArticle (Academic Journal)peer-review

69 Citations (Scopus)

Abstract

BACKGROUND: Augmented reflex response from peripheral chemoreceptors characterises chronic heart failure (CHF), contributes to autonomic imbalance and exercise intolerance and predicts poor outcome.

METHODS AND RESULTS: We present a case of a 56-year-old male patient with ischaemic CHF, who underwent surgical, unilateral carotid body resection to reduce peripheral chemosensitivity. At 2-month and 6-month follow-ups, we document a persistent decrease in peripheral chemosensitivity accompanied by an improvement in exercise capacity, sleep disordered breathing and quality of life. Autonomic balance was favourably affected as evidenced by improved heart rate variability and augmented cardiac baroreflex sensitivity. There were no procedure-related adverse events.

CONCLUSIONS: Denervation of a carotid body may offer a clinical strategy to restore autonomic balance and improve morbidity in heart failure (NCT01653821).

Original languageEnglish
Pages (from-to)2506-9
Number of pages4
JournalInternational Journal of Cardiology
Volume168
Issue number3
DOIs
Publication statusPublished - 3 Oct 2013

Bibliographical note

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Keywords

  • Carotid Body
  • Chronic Disease
  • Heart Failure, Systolic
  • Humans
  • Male
  • Middle Aged

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