Abstract
The generation of functional cartilage tissue using stem cells is promising to be an important advance in regenerative medicine. Whilst progress has been made using adult mesenchymal stem cells, these cells suffer from limited accessibility, senescence upon expansion and clonal variability. Investigating more potent stem cells such as embryonic stem cells and induced pluripotent stem cells could overcome a lot of those limitations but it also comes with its unique challenges. This review updates progress on therapies available for osteoarthritis, the development of cartilage, and provides an analysis of the recent attempts to use human embryonic stem cells in cartilage tissue engineering.
| Original language | English |
|---|---|
| Title of host publication | Comprehensive Biotechnology |
| Publisher | Elsevier |
| Pages | 213-214 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780444640475 |
| ISBN (Print) | 9780444640468 |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
Bibliographical note
Publisher Copyright:© 2016 Elsevier B.V. All rights reserved.
Keywords
- Cartilage
- Cartilage repair
- Cartilage tissue engineering
- Chondrogenesis
- Embryonic stem cell
- Induced pluripotent stem cell
- Joint traumatic injury
- Osteoarthritis
