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Abstract
The regiodivergent palladium-catalyzed CH arylation of pyrazolo[1,5-a]pyrimidine
has been achieved, wherein the switch in regioselectivity between
positions C3 and C7 is under complete catalyst control. A
phosphine-containing palladium catalyst promotes the direct arylation at
the most acidic position (C7), whereas a phosphine-free catalyst
targets the most electron-rich position (C3).
Original language | English |
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Pages (from-to) | 8787-8790 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 54 |
Issue number | 30 |
Early online date | 10 Jun 2015 |
DOIs | |
Publication status | Published - 20 Jul 2015 |
Structured keywords
- BCS and TECS CDTs
Keywords
- arylation
- C—H activation
- palladium
- regiocontrol
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Dive into the research topics of 'Catalyst-Switchable Regiocontrol in the Direct Arylation of Remote C—H Groups in Pyrazolo[1,5-a]pyrimidines'. Together they form a unique fingerprint.Projects
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Profiles
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Professor Robin B Bedford
- School of Chemistry - Professor of Catalysis
- Synthesis
- Supramolecular and Mechanistic Chemistry
- Catalysis
Person: Academic , Member