Catalytic and Highly Regenerable Aminic Organoselenium Antioxidants with Cytoprotective Effects

Manish Kumar, Paul J Gates, Vijay P. Singh*, et al.

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)

Abstract

Novel N‐methylated ebselenamine antioxidants were prepared from their corresponding diselenides with iodomethane. All ebselenamines showed excellent chain‐breaking and glutathione peroxidase (GPx)‐like activities. These could also inhibit the lipid peroxidation much more efficiently than α‐tocopherol. They could also mimic the functions of the GPx enzymes nearly two times better than ebselen in the coupled reductase assay. Also, these were found to scavenge the ROS produced at low concentration (10 μM) with low toxicity effects and would have the therapeutic potential against autoxidation. It is anticipated that these compounds would have the potential to be used in several diseases caused by autoxidation, and thus, providing protection for mammalians from cell death.
Original languageEnglish
Pages (from-to)2015-2022
Number of pages8
JournalOrganic and Biomolecular Chemistry
Volume(2021) 19
Issue number9
Early online date5 Feb 2021
DOIs
Publication statusPublished - 7 Mar 2021

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