Catalytic and Highly Regenerable Aminic Organoselenium Antioxidants with Cytoprotective Effects

Manish Kumar; Paul J Gates; Vijay P. Singh; et al.

doi:10.1039/D0OB02368J

Catalytic and Highly Regenerable Aminic Organoselenium Antioxidants with Cytoprotective Effects

Manish Kumar, Paul J Gates, Vijay P. Singh^*, et al.

^*Corresponding author for this work

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Abstract

Novel N‐methylated ebselenamine antioxidants were prepared from their corresponding diselenides with iodomethane. All ebselenamines showed excellent chain‐breaking and glutathione peroxidase (GPx)‐like activities. These could also inhibit the lipid peroxidation much more efficiently than α‐tocopherol. They could also mimic the functions of the GPx enzymes nearly two times better than ebselen in the coupled reductase assay. Also, these were found to scavenge the ROS produced at low concentration (10 μM) with low toxicity effects and would have the therapeutic potential against autoxidation. It is anticipated that these compounds would have the potential to be used in several diseases caused by autoxidation, and thus, providing protection for mammalians from cell death.

Original language	English
Pages (from-to)	2015-2022
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	(2021) 19
Issue number	9
Early online date	5 Feb 2021
DOIs	https://doi.org/10.1039/D0OB02368J
Publication status	Published - 7 Mar 2021

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title = "Catalytic and Highly Regenerable Aminic Organoselenium Antioxidants with Cytoprotective Effects",

abstract = "Novel N‐methylated ebselenamine antioxidants were prepared from their corresponding diselenides with iodomethane. All ebselenamines showed excellent chain‐breaking and glutathione peroxidase (GPx)‐like activities. These could also inhibit the lipid peroxidation much more efficiently than α‐tocopherol. They could also mimic the functions of the GPx enzymes nearly two times better than ebselen in the coupled reductase assay. Also, these were found to scavenge the ROS produced at low concentration (10 μM) with low toxicity effects and would have the therapeutic potential against autoxidation. It is anticipated that these compounds would have the potential to be used in several diseases caused by autoxidation, and thus, providing protection for mammalians from cell death.",

author = "Manish Kumar and Gates, {Paul J} and Singh, {Vijay P.} and {et al.}",

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doi = "10.1039/D0OB02368J",

language = "English",

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journal = "Organic and Biomolecular Chemistry",

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T1 - Catalytic and Highly Regenerable Aminic Organoselenium Antioxidants with Cytoprotective Effects

AU - Kumar, Manish

AU - Gates, Paul J

AU - Singh, Vijay P.

AU - et al.

PY - 2021/3/7

Y1 - 2021/3/7

N2 - Novel N‐methylated ebselenamine antioxidants were prepared from their corresponding diselenides with iodomethane. All ebselenamines showed excellent chain‐breaking and glutathione peroxidase (GPx)‐like activities. These could also inhibit the lipid peroxidation much more efficiently than α‐tocopherol. They could also mimic the functions of the GPx enzymes nearly two times better than ebselen in the coupled reductase assay. Also, these were found to scavenge the ROS produced at low concentration (10 μM) with low toxicity effects and would have the therapeutic potential against autoxidation. It is anticipated that these compounds would have the potential to be used in several diseases caused by autoxidation, and thus, providing protection for mammalians from cell death.

AB - Novel N‐methylated ebselenamine antioxidants were prepared from their corresponding diselenides with iodomethane. All ebselenamines showed excellent chain‐breaking and glutathione peroxidase (GPx)‐like activities. These could also inhibit the lipid peroxidation much more efficiently than α‐tocopherol. They could also mimic the functions of the GPx enzymes nearly two times better than ebselen in the coupled reductase assay. Also, these were found to scavenge the ROS produced at low concentration (10 μM) with low toxicity effects and would have the therapeutic potential against autoxidation. It is anticipated that these compounds would have the potential to be used in several diseases caused by autoxidation, and thus, providing protection for mammalians from cell death.

U2 - 10.1039/D0OB02368J

DO - 10.1039/D0OB02368J

M3 - Article (Academic Journal)

VL - (2021) 19

SP - 2015

EP - 2022

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 9

ER -

Catalytic and Highly Regenerable Aminic Organoselenium Antioxidants with Cytoprotective Effects

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