Skip to content

Catalytic processing in ruthenium-based polyoxometalate coacervate protocells

Research output: Contribution to journalArticle

Original languageEnglish
Article number41 (2020)
Number of pages9
JournalNature Communications
Volume11
Issue number1
DOIs
DateAccepted/In press - 19 Nov 2019
DatePublished (current) - 3 Jan 2020

Abstract

The development of programmable microscale materials with cell-like functions, dynamics and collective behaviour is an important milestone in systems chemistry, soft matter bioengineering and synthetic protobiology. Here, polymer/nucleotide coacervate micro-droplets are reconfigured into membrane-bounded polyoxometalate coacervate vesicles (PCVs) in the presence of a bio-inspired Ru-based polyoxometalate catalyst to produce synzyme protocells (Ru4PCVs) with catalase-like activity. We exploit the synthetic protocells for the implementation of multi-compartmentalized cell-like models capable of collective synzyme-mediated buoyancy, parallel catalytic processing in individual horseradish peroxidase-containing Ru4PCVs, and chemical signalling in distributed or encapsulated multi-catalytic protocell communities. Our results highlight a new type of catalytic micro-compartment with multi-functional activity and provide a step towards the development of protocell reaction networks.

    Research areas

  • Synthetic biology

    Structured keywords

  • BrisSynBio
  • Bristol BioDesign Institute

Download statistics

No data available

Documents

Documents

  • Full-text PDF (final published version)

    Rights statement: This is the final published version of the article (version of record). It first appeared online via Springer Nature at https://www.nature.com/articles/s41467-019-13759-1. Please refer to any applicable terms of use of the publisher.

    Final published version, 3.05 MB, PDF document

    Licence: CC BY

DOI

View research connections

Related faculties, schools or groups