Catecholaminergic modulation of trust decisions

Cătălina E Rățală; Sean J Fallon; Marieke E van der Schaaf; Niels Ter Huurne; Roshan Cools; Alan G Sanfey

doi:10.1007/s00213-019-5165-z

Catecholaminergic modulation of trust decisions

Cătălina E Rățală, Sean J Fallon, Marieke E van der Schaaf, Niels Ter Huurne, Roshan Cools, Alan G Sanfey

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Abstract

RATIONALE: Trust is a key component of social interactions. In order to assess the trustworthiness of others, people rely on both information learned from previous encounters, as well as on implicit biases associated with specific facial features.

OBJECTIVE: Here, we investigated the role of catecholamine (dopamine and noradrenaline) transmission on trust decisions as a function of both experienced behavior and facial features.

METHODS: To increase catecholamine levels, methylphenidate (MPH, i.e., Ritalin®, 20 mg) was administered to participants (N = 24) prior to their playing a well-studied economic task, namely the Trust Game (Berg et al. 1995). We measured the amount of money invested with a variety of game partners. Across game partners, we manipulated two aspects of trust: the facial trust level (high facial trust, low facial trust, and non-social) and the likelihood of reciprocation (high, low).

RESULTS: Results demonstrated no main effect of MPH on investments, but rather a selective lowering of investments under MPH as compared with placebo with the game partners who were low on facial trustworthiness and were low reciprocators.

CONCLUSION: These results provide evidence that MPH administration impacts social trust decision-making, but does so in a context-specific manner.

Original language	English
Pages (from-to)	1807-1816
Number of pages	10
Journal	Psychopharmacology
Volume	236
Issue number	6
Early online date	31 Jan 2019
DOIs	https://doi.org/10.1007/s00213-019-5165-z
Publication status	Published - 1 Jun 2019

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@article{342ce0ac00b640f19a4200fcde6dfc06,

title = "Catecholaminergic modulation of trust decisions",

abstract = "RATIONALE: Trust is a key component of social interactions. In order to assess the trustworthiness of others, people rely on both information learned from previous encounters, as well as on implicit biases associated with specific facial features.OBJECTIVE: Here, we investigated the role of catecholamine (dopamine and noradrenaline) transmission on trust decisions as a function of both experienced behavior and facial features.METHODS: To increase catecholamine levels, methylphenidate (MPH, i.e., Ritalin{\textregistered}, 20 mg) was administered to participants (N = 24) prior to their playing a well-studied economic task, namely the Trust Game (Berg et al. 1995). We measured the amount of money invested with a variety of game partners. Across game partners, we manipulated two aspects of trust: the facial trust level (high facial trust, low facial trust, and non-social) and the likelihood of reciprocation (high, low).RESULTS: Results demonstrated no main effect of MPH on investments, but rather a selective lowering of investments under MPH as compared with placebo with the game partners who were low on facial trustworthiness and were low reciprocators.CONCLUSION: These results provide evidence that MPH administration impacts social trust decision-making, but does so in a context-specific manner.",

author = "R{\u a}țal{\u a}, {C{\u a}t{\u a}lina E} and Fallon, {Sean J} and {van der Schaaf}, {Marieke E} and {Ter Huurne}, Niels and Roshan Cools and Sanfey, {Alan G}",

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doi = "10.1007/s00213-019-5165-z",

language = "English",

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journal = "Psychopharmacology",

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T1 - Catecholaminergic modulation of trust decisions

AU - Rățală, Cătălina E

AU - Fallon, Sean J

AU - van der Schaaf, Marieke E

AU - Ter Huurne, Niels

AU - Cools, Roshan

AU - Sanfey, Alan G

PY - 2019/6/1

Y1 - 2019/6/1

N2 - RATIONALE: Trust is a key component of social interactions. In order to assess the trustworthiness of others, people rely on both information learned from previous encounters, as well as on implicit biases associated with specific facial features.OBJECTIVE: Here, we investigated the role of catecholamine (dopamine and noradrenaline) transmission on trust decisions as a function of both experienced behavior and facial features.METHODS: To increase catecholamine levels, methylphenidate (MPH, i.e., Ritalin®, 20 mg) was administered to participants (N = 24) prior to their playing a well-studied economic task, namely the Trust Game (Berg et al. 1995). We measured the amount of money invested with a variety of game partners. Across game partners, we manipulated two aspects of trust: the facial trust level (high facial trust, low facial trust, and non-social) and the likelihood of reciprocation (high, low).RESULTS: Results demonstrated no main effect of MPH on investments, but rather a selective lowering of investments under MPH as compared with placebo with the game partners who were low on facial trustworthiness and were low reciprocators.CONCLUSION: These results provide evidence that MPH administration impacts social trust decision-making, but does so in a context-specific manner.

AB - RATIONALE: Trust is a key component of social interactions. In order to assess the trustworthiness of others, people rely on both information learned from previous encounters, as well as on implicit biases associated with specific facial features.OBJECTIVE: Here, we investigated the role of catecholamine (dopamine and noradrenaline) transmission on trust decisions as a function of both experienced behavior and facial features.METHODS: To increase catecholamine levels, methylphenidate (MPH, i.e., Ritalin®, 20 mg) was administered to participants (N = 24) prior to their playing a well-studied economic task, namely the Trust Game (Berg et al. 1995). We measured the amount of money invested with a variety of game partners. Across game partners, we manipulated two aspects of trust: the facial trust level (high facial trust, low facial trust, and non-social) and the likelihood of reciprocation (high, low).RESULTS: Results demonstrated no main effect of MPH on investments, but rather a selective lowering of investments under MPH as compared with placebo with the game partners who were low on facial trustworthiness and were low reciprocators.CONCLUSION: These results provide evidence that MPH administration impacts social trust decision-making, but does so in a context-specific manner.

U2 - 10.1007/s00213-019-5165-z

DO - 10.1007/s00213-019-5165-z

M3 - Article (Academic Journal)

C2 - 30706097

SN - 0033-3158

VL - 236

SP - 1807

EP - 1816

JO - Psychopharmacology

JF - Psychopharmacology

IS - 6

ER -

Catecholaminergic modulation of trust decisions

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