Cats with Inflammatory Bowel Disease and Intestinal Small Cell Lymphoma Have Low Serum Concentrations of 25-Hydroxyvitamin D

S. Lalor*, A. M. Schwartz, H. Titmarsh, N. Reed, S. Tasker, L. Boland, J. Berry, D. Gunn-Moore, R. J. Mellanby

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

17 Citations (Scopus)



Inflammatory bowel disease (IBD) and intestinal small cell lymphoma (ISCL) are common diseases in cats. The prevalence of alterations in the serum concentrations of fat soluble vitamins, such as vitamin D, in cats with IBD and ISCL is unknown.


The objective of this study was to measure serum 25 hydroxyvitamin D (25[OH]D) concentrations in cats with IBD or ISCL. Serum 25(OH)D also was measured in healthy cats, and in hospitalized ill cats with nongastrointestinal diseases.


Eighty-four cats were included in the study: 23 in the healthy group, 41 in the hospitalized ill group, and 20 in the IBD/ISCL group.


Retrospective study. Serum samples for vitamin D analysis were frozen at -20 degrees C until serum 25(OH)D was measured by high-performance liquid chromatography (HPLC).


Although there was overlap in serum 25(OH)D concentrations among the 3 groups, serum 25(OH)D concentrations were significantly lower in the cats with IBD or ISCL compared to healthy cats (P

Conclusion and Clinical Importance

The median serum concentration of 25(OH)D was significantly lower in cats with IBD/ISCL than in healthy cats and in hospitalized ill cats. Additional studies are required to elucidate the mechanism of hypovitaminosis D in cats with gastrointestinal diseases, to define the best management strategy to treat this complication, and to investigate its potential prognostic implications.

Original languageEnglish
Pages (from-to)351-355
Number of pages5
JournalJournal of Veterinary Internal Medicine
Issue number2
Publication statusPublished - 1 Mar 2014


  • Calcium
  • Inflammatory bowel disease
  • Vitamin D
  • Small cell lymphoma
  • DOGS

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