Cats with Inflammatory Bowel Disease and Intestinal Small Cell Lymphoma Have Low Serum Concentrations of 25-Hydroxyvitamin D

S. Lalor; A. M. Schwartz; H. Titmarsh; N. Reed; S. Tasker; L. Boland; J. Berry; D. Gunn-Moore; R. J. Mellanby

doi:10.1111/jvim.12294

Cats with Inflammatory Bowel Disease and Intestinal Small Cell Lymphoma Have Low Serum Concentrations of 25-Hydroxyvitamin D

S. Lalor^*, A. M. Schwartz, H. Titmarsh, N. Reed, S. Tasker, L. Boland, J. Berry, D. Gunn-Moore, R. J. Mellanby

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal)

14 Citations (Scopus)

Abstract

Background

Inflammatory bowel disease (IBD) and intestinal small cell lymphoma (ISCL) are common diseases in cats. The prevalence of alterations in the serum concentrations of fat soluble vitamins, such as vitamin D, in cats with IBD and ISCL is unknown.

Hypothesis/Objectives

The objective of this study was to measure serum 25 hydroxyvitamin D (25[OH]D) concentrations in cats with IBD or ISCL. Serum 25(OH)D also was measured in healthy cats, and in hospitalized ill cats with nongastrointestinal diseases.

Animals

Eighty-four cats were included in the study: 23 in the healthy group, 41 in the hospitalized ill group, and 20 in the IBD/ISCL group.

Methods

Retrospective study. Serum samples for vitamin D analysis were frozen at -20 degrees C until serum 25(OH)D was measured by high-performance liquid chromatography (HPLC).

Results

Although there was overlap in serum 25(OH)D concentrations among the 3 groups, serum 25(OH)D concentrations were significantly lower in the cats with IBD or ISCL compared to healthy cats (P

Conclusion and Clinical Importance

The median serum concentration of 25(OH)D was significantly lower in cats with IBD/ISCL than in healthy cats and in hospitalized ill cats. Additional studies are required to elucidate the mechanism of hypovitaminosis D in cats with gastrointestinal diseases, to define the best management strategy to treat this complication, and to investigate its potential prognostic implications.

Original language	English
Pages (from-to)	351-355
Number of pages	5
Journal	Journal of Veterinary Internal Medicine
Volume	28
Issue number	2
DOIs	https://doi.org/10.1111/jvim.12294
Publication status	Published - 1 Mar 2014

Keywords

Calcium
Inflammatory bowel disease
Vitamin D
Small cell lymphoma
VITAMIN-D STATUS
DOGS
HYPERADRENOCORTICISM

Access to Document

10.1111/jvim.12294

Link to publication in Scopus

Cite this

Lalor, S., Schwartz, A. M., Titmarsh, H., Reed, N., Tasker, S., Boland, L., Berry, J., Gunn-Moore, D., & Mellanby, R. J. (2014). Cats with Inflammatory Bowel Disease and Intestinal Small Cell Lymphoma Have Low Serum Concentrations of 25-Hydroxyvitamin D. Journal of Veterinary Internal Medicine, 28(2), 351-355. https://doi.org/10.1111/jvim.12294

@article{141b13bdc8c0461691f900e52ed168c8,

title = "Cats with Inflammatory Bowel Disease and Intestinal Small Cell Lymphoma Have Low Serum Concentrations of 25-Hydroxyvitamin D",

abstract = "Background Inflammatory bowel disease (IBD) and intestinal small cell lymphoma (ISCL) are common diseases in cats. The prevalence of alterations in the serum concentrations of fat soluble vitamins, such as vitamin D, in cats with IBD and ISCL is unknown. Hypothesis/Objectives The objective of this study was to measure serum 25 hydroxyvitamin D (25[OH]D) concentrations in cats with IBD or ISCL. Serum 25(OH)D also was measured in healthy cats, and in hospitalized ill cats with nongastrointestinal diseases. Animals Eighty-four cats were included in the study: 23 in the healthy group, 41 in the hospitalized ill group, and 20 in the IBD/ISCL group. Methods Retrospective study. Serum samples for vitamin D analysis were frozen at -20 degrees C until serum 25(OH)D was measured by high-performance liquid chromatography (HPLC). Results Although there was overlap in serum 25(OH)D concentrations among the 3 groups, serum 25(OH)D concentrations were significantly lower in the cats with IBD or ISCL compared to healthy cats (P Conclusion and Clinical Importance The median serum concentration of 25(OH)D was significantly lower in cats with IBD/ISCL than in healthy cats and in hospitalized ill cats. Additional studies are required to elucidate the mechanism of hypovitaminosis D in cats with gastrointestinal diseases, to define the best management strategy to treat this complication, and to investigate its potential prognostic implications.",

keywords = "Calcium, Inflammatory bowel disease, Vitamin D, Small cell lymphoma, VITAMIN-D STATUS, DOGS, HYPERADRENOCORTICISM",

author = "S. Lalor and Schwartz, {A. M.} and H. Titmarsh and N. Reed and S. Tasker and L. Boland and J. Berry and D. Gunn-Moore and Mellanby, {R. J.}",

year = "2014",

month = mar,

day = "1",

doi = "10.1111/jvim.12294",

language = "English",

volume = "28",

pages = "351--355",

journal = "Journal of Veterinary Internal Medicine",

issn = "0891-6640",

publisher = "Wiley",

number = "2",

}

Cats with Inflammatory Bowel Disease and Intestinal Small Cell Lymphoma Have Low Serum Concentrations of 25-Hydroxyvitamin D. / Lalor, S.; Schwartz, A. M.; Titmarsh, H.; Reed, N.; Tasker, S.; Boland, L.; Berry, J.; Gunn-Moore, D.; Mellanby, R. J.

In: Journal of Veterinary Internal Medicine, Vol. 28, No. 2, 01.03.2014, p. 351-355.

Research output: Contribution to journal › Article (Academic Journal)

TY - JOUR

T1 - Cats with Inflammatory Bowel Disease and Intestinal Small Cell Lymphoma Have Low Serum Concentrations of 25-Hydroxyvitamin D

AU - Lalor, S.

AU - Schwartz, A. M.

AU - Titmarsh, H.

AU - Reed, N.

AU - Tasker, S.

AU - Boland, L.

AU - Berry, J.

AU - Gunn-Moore, D.

AU - Mellanby, R. J.

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Background Inflammatory bowel disease (IBD) and intestinal small cell lymphoma (ISCL) are common diseases in cats. The prevalence of alterations in the serum concentrations of fat soluble vitamins, such as vitamin D, in cats with IBD and ISCL is unknown. Hypothesis/Objectives The objective of this study was to measure serum 25 hydroxyvitamin D (25[OH]D) concentrations in cats with IBD or ISCL. Serum 25(OH)D also was measured in healthy cats, and in hospitalized ill cats with nongastrointestinal diseases. Animals Eighty-four cats were included in the study: 23 in the healthy group, 41 in the hospitalized ill group, and 20 in the IBD/ISCL group. Methods Retrospective study. Serum samples for vitamin D analysis were frozen at -20 degrees C until serum 25(OH)D was measured by high-performance liquid chromatography (HPLC). Results Although there was overlap in serum 25(OH)D concentrations among the 3 groups, serum 25(OH)D concentrations were significantly lower in the cats with IBD or ISCL compared to healthy cats (P Conclusion and Clinical Importance The median serum concentration of 25(OH)D was significantly lower in cats with IBD/ISCL than in healthy cats and in hospitalized ill cats. Additional studies are required to elucidate the mechanism of hypovitaminosis D in cats with gastrointestinal diseases, to define the best management strategy to treat this complication, and to investigate its potential prognostic implications.

AB - Background Inflammatory bowel disease (IBD) and intestinal small cell lymphoma (ISCL) are common diseases in cats. The prevalence of alterations in the serum concentrations of fat soluble vitamins, such as vitamin D, in cats with IBD and ISCL is unknown. Hypothesis/Objectives The objective of this study was to measure serum 25 hydroxyvitamin D (25[OH]D) concentrations in cats with IBD or ISCL. Serum 25(OH)D also was measured in healthy cats, and in hospitalized ill cats with nongastrointestinal diseases. Animals Eighty-four cats were included in the study: 23 in the healthy group, 41 in the hospitalized ill group, and 20 in the IBD/ISCL group. Methods Retrospective study. Serum samples for vitamin D analysis were frozen at -20 degrees C until serum 25(OH)D was measured by high-performance liquid chromatography (HPLC). Results Although there was overlap in serum 25(OH)D concentrations among the 3 groups, serum 25(OH)D concentrations were significantly lower in the cats with IBD or ISCL compared to healthy cats (P Conclusion and Clinical Importance The median serum concentration of 25(OH)D was significantly lower in cats with IBD/ISCL than in healthy cats and in hospitalized ill cats. Additional studies are required to elucidate the mechanism of hypovitaminosis D in cats with gastrointestinal diseases, to define the best management strategy to treat this complication, and to investigate its potential prognostic implications.

KW - Calcium

KW - Inflammatory bowel disease

KW - Vitamin D

KW - Small cell lymphoma

KW - VITAMIN-D STATUS

KW - DOGS

KW - HYPERADRENOCORTICISM

UR - http://www.scopus.com/inward/record.url?scp=84897606462&partnerID=8YFLogxK

U2 - 10.1111/jvim.12294

DO - 10.1111/jvim.12294

M3 - Article (Academic Journal)

C2 - 24433362

VL - 28

SP - 351

EP - 355

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 2

ER -