Cell adhesion molecule expression in the cervix and myometrium during pregnancy and parturition

M. A. Ledingham, A. J. Thomson, F. Jordan, A. Young, M. Crawford, J. E. Norman

Research output: Contribution to journalArticle (Academic Journal)

Abstract

OBJECTIVE: To determine the expression and localization of cell adhesion molecules intercellular adhesion molecule-1 (ICAM-1), E-selectin, platelet-endothelial cell adhesion molecule (PECAM), and vascular cell adhesion molecule (VCAM) in the cervix and myometrium during pregnancy and labor.METHODS: Biopsies of myometrium and cervix were obtained from non-pregnant women and from pregnant women before and after onset of spontaneous labor at term. Cell adhesion molecule mRNA expression was quantified using Northern blotting and cell adhesion molecule protein was localized using immunohistochemistry.RESULTS: ICAM-1 mRNA was upregulated in the cervix (10-fold increase, P
Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalObstetrics and Gynecology
Volume97
Issue number2
Publication statusPublished - 2001

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Keywords

  • Adult Antigens, CD31 Cell Adhesion Molecules Cervix Uteri E-Selectin Female Gene Expression Humans Infant, Newborn Intercellular Adhesion Molecule-1 Labor, Obstetric Myometrium Pregnancy RNA, Messenger Reference Values Vascular Cell Adhesion Molecule-1

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