Cell adhesion molecule expression in the cervix and myometrium during pregnancy and parturition

M. A. Ledingham; A. J. Thomson; F. Jordan; A. Young; M. Crawford; J. E. Norman

Cell adhesion molecule expression in the cervix and myometrium during pregnancy and parturition

M. A. Ledingham, A. J. Thomson, F. Jordan, A. Young, M. Crawford, J. E. Norman

Health Sciences Faculty Office

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Abstract

OBJECTIVE: To determine the expression and localization of cell adhesion molecules intercellular adhesion molecule-1 (ICAM-1), E-selectin, platelet-endothelial cell adhesion molecule (PECAM), and vascular cell adhesion molecule (VCAM) in the cervix and myometrium during pregnancy and labor.METHODS: Biopsies of myometrium and cervix were obtained from non-pregnant women and from pregnant women before and after onset of spontaneous labor at term. Cell adhesion molecule mRNA expression was quantified using Northern blotting and cell adhesion molecule protein was localized using immunohistochemistry.RESULTS: ICAM-1 mRNA was upregulated in the cervix (10-fold increase, P

Original language	English
Pages (from-to)	235-242
Number of pages	8
Journal	Obstetrics and Gynecology
Volume	97
Issue number	2
Publication status	Published - 2001

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Keywords

Adult Antigens, CD31 Cell Adhesion Molecules Cervix Uteri E-Selectin Female Gene Expression Humans Infant, Newborn Intercellular Adhesion Molecule-1 Labor, Obstetric Myometrium Pregnancy RNA, Messenger Reference Values Vascular Cell Adhesion Molecule-1

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@article{64a44c7b591b47f7828a81b3661c9054,

title = "Cell adhesion molecule expression in the cervix and myometrium during pregnancy and parturition",

abstract = "OBJECTIVE: To determine the expression and localization of cell adhesion molecules intercellular adhesion molecule-1 (ICAM-1), E-selectin, platelet-endothelial cell adhesion molecule (PECAM), and vascular cell adhesion molecule (VCAM) in the cervix and myometrium during pregnancy and labor.METHODS: Biopsies of myometrium and cervix were obtained from non-pregnant women and from pregnant women before and after onset of spontaneous labor at term. Cell adhesion molecule mRNA expression was quantified using Northern blotting and cell adhesion molecule protein was localized using immunohistochemistry.RESULTS: ICAM-1 mRNA was upregulated in the cervix (10-fold increase, P ",

keywords = "Adult Antigens, CD31 Cell Adhesion Molecules Cervix Uteri E-Selectin Female Gene Expression Humans Infant, Newborn Intercellular Adhesion Molecule-1 Labor, Obstetric Myometrium Pregnancy RNA, Messenger Reference Values Vascular Cell Adhesion Molecule-1",

author = "Ledingham, {M. A.} and Thomson, {A. J.} and F. Jordan and A. Young and M. Crawford and Norman, {J. E.}",

note = "RIS file",

year = "2001",

language = "English",

volume = "97",

pages = "235--242",

journal = "Obstetrics and Gynecology",

issn = "0029-7844",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - Cell adhesion molecule expression in the cervix and myometrium during pregnancy and parturition

AU - Ledingham, M. A.

AU - Thomson, A. J.

AU - Jordan, F.

AU - Young, A.

AU - Crawford, M.

AU - Norman, J. E.

N1 - RIS file

PY - 2001

Y1 - 2001

N2 - OBJECTIVE: To determine the expression and localization of cell adhesion molecules intercellular adhesion molecule-1 (ICAM-1), E-selectin, platelet-endothelial cell adhesion molecule (PECAM), and vascular cell adhesion molecule (VCAM) in the cervix and myometrium during pregnancy and labor.METHODS: Biopsies of myometrium and cervix were obtained from non-pregnant women and from pregnant women before and after onset of spontaneous labor at term. Cell adhesion molecule mRNA expression was quantified using Northern blotting and cell adhesion molecule protein was localized using immunohistochemistry.RESULTS: ICAM-1 mRNA was upregulated in the cervix (10-fold increase, P

AB - OBJECTIVE: To determine the expression and localization of cell adhesion molecules intercellular adhesion molecule-1 (ICAM-1), E-selectin, platelet-endothelial cell adhesion molecule (PECAM), and vascular cell adhesion molecule (VCAM) in the cervix and myometrium during pregnancy and labor.METHODS: Biopsies of myometrium and cervix were obtained from non-pregnant women and from pregnant women before and after onset of spontaneous labor at term. Cell adhesion molecule mRNA expression was quantified using Northern blotting and cell adhesion molecule protein was localized using immunohistochemistry.RESULTS: ICAM-1 mRNA was upregulated in the cervix (10-fold increase, P

KW - Adult Antigens, CD31 Cell Adhesion Molecules Cervix Uteri E-Selectin Female Gene Expression Humans Infant, Newborn Intercellular Adhesion Molecule-1 Labor, Obstetric Myometrium Pregnancy RNA, Messenger Reference Values Vascular Cell Adhesion Molecule-1

M3 - Article (Academic Journal)

SN - 0029-7844

VL - 97

SP - 235

EP - 242

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

IS - 2

ER -

Cell adhesion molecule expression in the cervix and myometrium during pregnancy and parturition

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