Cell Competition Modifies Adult Stem Cell and Tissue Population Dynamics in a JAK-STAT-Dependent Manner

Golnar Kolahgar, Saskia J E Suijkerbuijk, Iwo Kucinski, Enzo Z Poirier, Sarah Mansour, Benjamin D Simons, Eugenia Piddini

Research output: Contribution to journalArticle (Academic Journal)

48 Citations (Scopus)

Abstract

Throughout their lifetime, cells may suffer insults that reduce their fitness and disrupt their function, and it is unclear how these potentially harmful cells are managed in adult tissues. We address this question using the adult Drosophila posterior midgut as a model of homeostatic tissue and ribosomal Minute mutations to reduce fitness in groups of cells. We take a quantitative approach combining lineage tracing and biophysical modeling and address how cell competition affects stem cell and tissue population dynamics. We show that healthy cells induce clonal extinction in weak tissues, targeting both stem and differentiated cells for elimination. We also find that competition induces stem cell proliferation and self-renewal in healthy tissue, promoting selective advantage and tissue colonization. Finally, we show that winner cell proliferation is fueled by the JAK-STAT ligand Unpaired-3, produced by Minute(-/+) cells in response to chronic JNK stress signaling.

Original languageEnglish
Pages (from-to)297-309
Number of pages13
JournalDevelopmental Cell
Volume34
Issue number3
DOIs
Publication statusPublished - 10 Aug 2015

Keywords

  • Adult Stem Cells
  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Cell Proliferation
  • Drosophila Proteins
  • Drosophila melanogaster
  • JNK Mitogen-Activated Protein Kinases
  • Janus Kinases
  • MAP Kinase Signaling System
  • Ribosomes
  • STAT Transcription Factors
  • Transcription Factors
  • Journal Article
  • Research Support, Non-U.S. Gov't

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    Cite this

    Kolahgar, G., Suijkerbuijk, S. J. E., Kucinski, I., Poirier, E. Z., Mansour, S., Simons, B. D., & Piddini, E. (2015). Cell Competition Modifies Adult Stem Cell and Tissue Population Dynamics in a JAK-STAT-Dependent Manner. Developmental Cell, 34(3), 297-309. https://doi.org/10.1016/j.devcel.2015.06.010