Cell-Specific Targeting of Genetically Encoded Tools for Neuroscience

Lucas Sjulson, Daniela Cassataro, Shamik DasGupta, Gero Miesenböck

Research output: Contribution to journalReview article (Academic Journal)peer-review

38 Citations (Scopus)


Genetically encoded tools for visualizing and manipulating neurons in vivo have led to significant advances in neuroscience, in large part because of the ability to target expression to specific cell populations of interest. Current methods enable targeting based on marker gene expression, development, anatomical projection pattern, synaptic connectivity, and recent activity as well as combinations of these factors. Here, we review these methods, focusing on issues of practical implementation as well as areas for future improvement.

Original languageEnglish
Pages (from-to)571-594
Number of pages24
JournalAnnual Review of Genetics
Publication statusPublished - 23 Nov 2016


  • Animals
  • Animals, Genetically Modified
  • Gene Expression
  • Gene Transfer Techniques
  • Genetic Techniques
  • Humans
  • Neurons/physiology
  • Neurosciences/methods
  • Promoter Regions, Genetic
  • Transgenes


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