Cellular structures controlling T cell signaling in time and space

Christoph Wülfing, Kole Roybal

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

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T cell signaling is characterized by the diverse enrichment of receptors and signaling intermediates at particular subcellular regions of the T cell at specific times, resulting in complex spatiotemporal signaling distributions. These signaling distributions control the flow of information through the T cell signaling network and thus govern the efficiency of cellular activation. Here we discuss principal cellular structures driving the organization of T cell signaling including membrane topology, vesicular trafficking, cytoskeletal structures and protein complexes.
Original languageEnglish
Title of host publicationEncyclopedia of Cell Biology
Editorsralph bradshaw, Philip Stahl
Place of PublicationWaltham, MA
PublisherAcademic Press
ISBN (Print)9780123944474
Publication statusPublished - 26 Oct 2015


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