T cell signaling is characterized by the diverse enrichment of receptors and signaling intermediates at particular subcellular regions of the T cell at specific times, resulting in complex spatiotemporal signaling distributions. These signaling distributions control the flow of information through the T cell signaling network and thus govern the efficiency of cellular activation. Here we discuss principal cellular structures driving the organization of T cell signaling including membrane topology, vesicular trafficking, cytoskeletal structures and protein complexes.
|Title of host publication||Encyclopedia of Cell Biology|
|Editors||ralph bradshaw, Philip Stahl|
|Place of Publication||Waltham, MA|
|Publication status||Published - 26 Oct 2015|
Wülfing, C., & Roybal, K. (2015). Cellular structures controlling T cell signaling in time and space. In R. bradshaw, & P. Stahl (Eds.), Encyclopedia of Cell Biology (Vol. 3, pp. 677-686). Academic Press. https://doi.org/10.1016/B978-0-12-394447-4.30102-X