Cellular Structures Controlling T Cell Signaling in Time and Space

Kole T. Roybal; Hanin I A Alamir; Jiahe Lu; Christoph Wuelfing

doi:10.1016/B978-0-12-821618-7.00010-9

Cellular Structures Controlling T Cell Signaling in Time and Space

Kole T. Roybal, Hanin I A Alamir, Jiahe Lu, Christoph Wuelfing

Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

Abstract

T cell signaling is characterized by the diverse enrichment of receptors and signaling intermediates at particular subcellular regions of the T cell at specific times, resulting in complex spatiotemporal signaling distributions. These signaling distributions control the flow of information through the T cell signaling network and thus govern the efficiency of cellular activation. Here we discuss principal cellular structures driving the organization of T cell signaling including membrane topology, vesicular trafficking, cytoskeletal structures and protein complexes.

Original language	English
Title of host publication	Encyclopedia of Cell Biology, Second Edition
Editors	Ralph A. Bradshaw, Gerald W. Hart, Philip D. Stahl
Place of Publication	Oxford
Publisher	Elsevier
Pages	563-577
Number of pages	15
Volume	5
Edition	2
ISBN (Print)	9780128216248
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.00010-9
Publication status	Published - 2023

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abstract = "T cell signaling is characterized by the diverse enrichment of receptors and signaling intermediates at particular subcellular regions of the T cell at specific times, resulting in complex spatiotemporal signaling distributions. These signaling distributions control the flow of information through the T cell signaling network and thus govern the efficiency of cellular activation. Here we discuss principal cellular structures driving the organization of T cell signaling including membrane topology, vesicular trafficking, cytoskeletal structures and protein complexes.",

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Cellular Structures Controlling T Cell Signaling in Time and Space. / Roybal, Kole T.; Alamir, Hanin I A; Lu, Jiahe et al.
Encyclopedia of Cell Biology, Second Edition. ed. / Ralph A. Bradshaw; Gerald W. Hart; Philip D. Stahl. Vol. 5 2. ed. Oxford: Elsevier, 2023. p. 563-577.

Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

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AU - Lu, Jiahe

AU - Wuelfing, Christoph

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AB - T cell signaling is characterized by the diverse enrichment of receptors and signaling intermediates at particular subcellular regions of the T cell at specific times, resulting in complex spatiotemporal signaling distributions. These signaling distributions control the flow of information through the T cell signaling network and thus govern the efficiency of cellular activation. Here we discuss principal cellular structures driving the organization of T cell signaling including membrane topology, vesicular trafficking, cytoskeletal structures and protein complexes.

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BT - Encyclopedia of Cell Biology, Second Edition

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A2 - Hart, Gerald W.

A2 - Stahl, Philip D.

PB - Elsevier

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Cellular Structures Controlling T Cell Signaling in Time and Space

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