Cerebellar dysfunction in multiple sclerosis

Alastair Wilkins

Research output: Contribution to journalArticle (Academic Journal)peer-review

18 Citations (Scopus)
292 Downloads (Pure)

Abstract

Multiple sclerosis (MS) commonly affects the cerebellum causing acute and chronic symptoms. Cerebellar signs contribute significantly to clinical disability, and symptoms such as tremor, ataxia, and dysarthria are particularly difficult to treat. Increasing knowledge concerning the pathophysiology of cerebellar disease in MS from human postmortem studies, experimental models, and clinical trials has raised the hope that cerebellar symptoms will be better treated in the future.
Original languageEnglish
Article number312
Number of pages6
JournalFrontiers in Neurology
Volume8
DOIs
Publication statusPublished - 28 Jun 2017

Keywords

  • multiple sclerosis,
  • purkinje cells
  • cerebellar diseases,
  • ataxia,
  • demyelinating diseases,

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