Cerebellar Prediction and Feeding Behaviour

Crissy Iosif*, Zafar I Bashir, R Apps, Jasmine Pickford

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

12 Citations (Scopus)

Abstract

Given the importance of the cerebellum in controlling movements, it might be expected that its main role in eating would be the control of motor elements such as chewing and swallowing. Whilst such functions are clearly important, there is more to eating than these actions, and more to the cerebellum than motor control. This review will present evidence that the cerebellum contributes to homeostatic, motor, rewarding and affective aspects of food consumption.Prediction and feedback underlie many elements of eating, as food consumption is influenced by expectation. For example, circadian clocks cause hunger in anticipation of a meal, and food consumption causes feedback signals which induce satiety. Similarly, the sight and smell of food generate an expectation of what that food will taste like, and its actual taste will generate an internal reward value which will be compared to that expectation. Cerebellar learning is widely thought to involve feed-forward predictions to compare expected outcomes to sensory feedback. We therefore propose that the overarching role of the cerebellum in eating is to respond to prediction errors arising across the homeostatic, motor, cognitive, and affective domains.
Original languageEnglish
Pages (from-to)1002-1019
Number of pages18
JournalCerebellum
Volume22
Issue number5
Early online date19 Sept 2022
DOIs
Publication statusPublished - 1 Oct 2023

Bibliographical note

Funding Information:
This work was supported by the Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership [BB/M009122/1] and the Biotechnology and Biological Sciences Research Council [BB/R017336/1].

Publisher Copyright:
© 2022, Crown.

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