CFD analysis for the evaluation of patient-specific hemodynamic parameters in cerebral aneurysms

Iolanda Velho, Jorge Tiago, Alberto Gambaruto, Adélia Sequeira, Vahid Goodarzi Ardakani, Xin Tu, Ricardo Pereira

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Abstract

Blood flow simulations are now considered a valuable tool for a deeper understanding of the physiopathology of intracranial aneurysms. Many authors built robust computational settings based on accurate computer-assisted registration, segmentation, and 3D geometry reconstruction from medical images of patient specific cerebral aneurysms, and special techniques to derive appropriate boundary conditions. However, an accurate description of flow mechanics in the near wall region and its connection with the evolution of the wall disease evolution remains linked to several questions not yet fully understood. Recently, several authors have suggested a lower order approximation of the Lagrangian dynamics in the near wall region, which allows for a meaningful characterization of both normal and parallel direction to the wall. We verify this computational approach with a cohort of brain aneurysms and try to provide a step further in the understanding of the hemodynamic
environment and its possible connection with the risk of rupture.

[1] V. Ardakani, I. Velho, X. Tu, A.M. Gambaruto, J. Tiago, R. Pereira, A. Sequeira, “Near-wall flow in cerebral aneurysms” Fluids, in press.

[2] A. Arzani, A.M. Gambaruto, G., Chen, S.C. Shadden, “Lagrangian wall shear stress structures and near-wall transport in high-Schmidt-number aneurysmal flows”. Journal of Fluid Mechanics, vol 790., pp. 158-172, 2016.

[3] A.M. Gambaruto, D.J. Doorly, and T. Yamaguchi, “Wall shear stress and near-wall convective transport: Comparisons with vascular remodeling in a peripheral graft anastomosis,” Journal of Computational Physics, vol. 229, no. 14, pp. 5339–5356, 2010.
Original languageEnglish
Title of host publication15th Mediterranean Conference on Medical and Biological Engineering and Computing
EditorsJorge Henriques, Nunu Neves, Paulo De Carvalho
PublisherSpringer
Pages1353-1360
Number of pages7
ISBN (Electronic)978-3-030-31635-8
ISBN (Print)978-3-030-31634-1
DOIs
Publication statusPublished - 25 Sep 2019
Event15th Mediterranean Conference on Medical and Biological Engineering and Computing (MEDICON2019) - Coimbra, Coimbra, Portugal
Duration: 26 Sep 201928 Sep 2019
http://www.medicon2019.org/

Publication series

NameIFMBE Proceedings
PublisherSpringer
Volume76
ISSN (Print)1680-0737
ISSN (Electronic)1433-9277

Conference

Conference15th Mediterranean Conference on Medical and Biological Engineering and Computing (MEDICON2019)
CountryPortugal
CityCoimbra
Period26/09/1928/09/19
Internet address

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