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Challenges to and Facilitators of Recruitment to an Alzheimer's Disease Clinical Trial: A Qualitative Interview Study

Research output: Contribution to journalArticle

Original languageEnglish
Number of pages9
JournalJournal of Alzheimer's Disease
Early online date25 May 2019
DOIs
DateAccepted/In press - 9 Apr 2019
DateE-pub ahead of print - 25 May 2019
DatePublished (current) - 18 Jun 2019

Abstract

Background
Low participation in clinical trials is a major challenge to advancing clinical Alzheimer’s Disease (AD) research and care. Factors influencing recruitment to AD trials are not fully understood.

Aims
To identify barriers to, and facilitators of, recruitment in a UK multi-centre, secondary care AD trial (Reducing pathology in Alzheimer’s Disease through Angiotensin TaRgeting (RADAR) trial) and implications for improving recruitment to AD trials.

Methods
Semi-structured qualitative telephone interviews with a purposive sample of 17 trial site staff explored the RADAR trial recruitment pathway and views and experiences of recruitment. Interviews were analysed thematically.

Results
Diagnostic and care pathways hindered identifying patients with mild-moderate AD, with a lack of up-to-date patient records and data access problems affecting screening. Research is not routinely embedded in AD care but facilitated recruitment when it was. Clinicians’ and patients’ favourable view of the trial purpose facilitated recruitment, although the complexity of participant information sheets and requirement for study companion created challenges.

Conclusion
These findings have important implications for the design of future AD trials and for planning how to best interface with clinical commitments to ensure sufficient and timely recruitment. Challenges to AD trial recruitment can occur at care pathway, clinician, and patient and companion levels. Recruitment can be facilitated by: improving diagnostic processes and systems for recording and sharing patient information, embedding research into routine patient care, collaborating with a range of services to identify and approach eligible patients, training and engaging trial staff, and providing patients with clear and concise study information.

    Structured keywords

  • BRTC
  • Centre for Surgical Research

    Research areas

  • Dementia, Randomized controlled trial, Qualitative Research, Patient Care, recruitment

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via IOS Press at https://doi.org/10.3233/JAD-190146 . Please refer to any applicable terms of use of the publisher.

    Final published version, 76 KB, PDF document

    Licence: CC BY-NC

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