Changes in CCK mRNA in hippocampal neurones following fimbria fornix transection

M K Panni, V J Wilson, U Capoor, M V Sofroniew, M Rattray

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)

Abstract

Preprocholecystokinin (CCK) mRNA expression was measured in a subset of hippocampal interneurones after transection of afferent septohippocampal fibres in the fimbria fornix. Two weeks after the lesions were made, CCK mRNA levels were significantly lower in these neurones on the side ipsilateral to the lesion compared with equivalent neurones on the unlesioned side. These findings suggest that axotomizing lesions can change gene expression in denervated target cells, and that CCK mRNA levels in hippocampal interneurones may be modulated by afferent septohippocampal input.

Original languageEnglish
Pages (from-to)1377-80
Number of pages4
JournalNeuroReport
Volume5
Issue number11
Publication statusPublished - 27 Jun 1994

Keywords

  • Afferent Pathways
  • Animals
  • Base Sequence
  • Cholecystokinin
  • Female
  • Gene Expression Regulation
  • Hippocampus
  • Interneurons
  • Molecular Sequence Data
  • Nerve Tissue Proteins
  • Protein Precursors
  • RNA, Messenger
  • Rats
  • Rats, Wistar
  • Septum Pellucidum
  • gamma-Aminobutyric Acid
  • Journal Article
  • Research Support, Non-U.S. Gov't

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