Changes in CCK mRNA in hippocampal neurones following fimbria fornix transection

M K Panni; V J Wilson; U Capoor; M V Sofroniew; M Rattray

Changes in CCK mRNA in hippocampal neurones following fimbria fornix transection

M K Panni
, V J Wilson
, U Capoor
, M V Sofroniew
, M Rattray

Research output: Contribution to journal › Article (Academic Journal) › peer-review

2 Citations (Scopus)

Abstract

Preprocholecystokinin (CCK) mRNA expression was measured in a subset of hippocampal interneurones after transection of afferent septohippocampal fibres in the fimbria fornix. Two weeks after the lesions were made, CCK mRNA levels were significantly lower in these neurones on the side ipsilateral to the lesion compared with equivalent neurones on the unlesioned side. These findings suggest that axotomizing lesions can change gene expression in denervated target cells, and that CCK mRNA levels in hippocampal interneurones may be modulated by afferent septohippocampal input.

Original language	English
Pages (from-to)	1377-80
Number of pages	4
Journal	NeuroReport
Volume	5
Issue number	11
Publication status	Published - 27 Jun 1994

Keywords

Afferent Pathways
Animals
Base Sequence
Cholecystokinin
Female
Gene Expression Regulation
Hippocampus
Interneurons
Molecular Sequence Data
Nerve Tissue Proteins
Protein Precursors
RNA, Messenger
Rats
Rats, Wistar
Septum Pellucidum
gamma-Aminobutyric Acid
Journal Article
Research Support, Non-U.S. Gov't

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@article{68a6a11dd35e43e79bbfde7c5e0de549,

title = "Changes in CCK mRNA in hippocampal neurones following fimbria fornix transection",

abstract = "Preprocholecystokinin (CCK) mRNA expression was measured in a subset of hippocampal interneurones after transection of afferent septohippocampal fibres in the fimbria fornix. Two weeks after the lesions were made, CCK mRNA levels were significantly lower in these neurones on the side ipsilateral to the lesion compared with equivalent neurones on the unlesioned side. These findings suggest that axotomizing lesions can change gene expression in denervated target cells, and that CCK mRNA levels in hippocampal interneurones may be modulated by afferent septohippocampal input.",

keywords = "Afferent Pathways, Animals, Base Sequence, Cholecystokinin, Female, Gene Expression Regulation, Hippocampus, Interneurons, Molecular Sequence Data, Nerve Tissue Proteins, Protein Precursors, RNA, Messenger, Rats, Rats, Wistar, Septum Pellucidum, gamma-Aminobutyric Acid, Journal Article, Research Support, Non-U.S. Gov't",

author = "Panni, \{M K\} and Wilson, \{V J\} and U Capoor and Sofroniew, \{M V\} and M Rattray",

year = "1994",

month = jun,

day = "27",

language = "English",

volume = "5",

pages = "1377--80",

journal = "NeuroReport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins",

number = "11",

}

TY - JOUR

T1 - Changes in CCK mRNA in hippocampal neurones following fimbria fornix transection

AU - Panni, M K

AU - Wilson, V J

AU - Capoor, U

AU - Sofroniew, M V

AU - Rattray, M

PY - 1994/6/27

Y1 - 1994/6/27

N2 - Preprocholecystokinin (CCK) mRNA expression was measured in a subset of hippocampal interneurones after transection of afferent septohippocampal fibres in the fimbria fornix. Two weeks after the lesions were made, CCK mRNA levels were significantly lower in these neurones on the side ipsilateral to the lesion compared with equivalent neurones on the unlesioned side. These findings suggest that axotomizing lesions can change gene expression in denervated target cells, and that CCK mRNA levels in hippocampal interneurones may be modulated by afferent septohippocampal input.

AB - Preprocholecystokinin (CCK) mRNA expression was measured in a subset of hippocampal interneurones after transection of afferent septohippocampal fibres in the fimbria fornix. Two weeks after the lesions were made, CCK mRNA levels were significantly lower in these neurones on the side ipsilateral to the lesion compared with equivalent neurones on the unlesioned side. These findings suggest that axotomizing lesions can change gene expression in denervated target cells, and that CCK mRNA levels in hippocampal interneurones may be modulated by afferent septohippocampal input.

KW - Afferent Pathways

KW - Animals

KW - Base Sequence

KW - Cholecystokinin

KW - Female

KW - Gene Expression Regulation

KW - Hippocampus

KW - Interneurons

KW - Molecular Sequence Data

KW - Nerve Tissue Proteins

KW - Protein Precursors

KW - RNA, Messenger

KW - Rats

KW - Rats, Wistar

KW - Septum Pellucidum

KW - gamma-Aminobutyric Acid

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Article (Academic Journal)

C2 - 7919204

SN - 0959-4965

VL - 5

SP - 1377

EP - 1380

JO - NeuroReport

JF - NeuroReport

IS - 11

ER -

Changes in CCK mRNA in hippocampal neurones following fimbria fornix transection

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