Changes in testosterone related to body composition in late midlife: Findings from the 1946 British birth cohort study

David Bann, Frederick C W Wu, Brian Keevil, Hany Lashen, Judith Adams, Rebecca Hardy, Graciela Muniz, Diana Kuh, Yoav Ben-Shlomo, Ken K Ong

Research output: Contribution to journalArticle (Academic Journal)peer-review

19 Citations (Scopus)

Abstract

OBJECTIVE: Randomized trials in men with testosterone deficiency have provided evidence of short-term effects of testosterone therapy on muscle and fat mass but it is unclear whether this persists over a longer period or how testosterone affects women. We examined whether the midlife decline in testosterone relates to fat and lean mass in both sexes.

METHODS: Data were collected from 440 men and 560 women participating in the 1946 British birth cohort study with testosterone measured at 53 and/or 60-64 years. Fat and appendicular lean mass were measured at 60-64 years using dual-energy X-ray absorptiometry.

RESULTS: Mean free testosterone concentrations were lower at 60-64 than 53 years, by 26% in both sexes. At both ages testosterone was negatively associated with fat mass in men and positively associated in women. A larger decline in free testosterone was associated with higher fat mass in men but with lower fat mass among women. In contrast, declines in testosterone were not associated with lean mass in either sex.

CONCLUSIONS: Our findings suggest sex-divergent relationships between testosterone and fat mass and their distribution but do not support the hypothesis that midlife declines in testosterone lead to lower lean mass.

Original languageEnglish
JournalObesity
DOIs
Publication statusPublished - 5 Jun 2015

Bibliographical note

© 2015 The Obesity Society.

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