Changing epidemiology of bacterial meningitis among adults in England and Wales 1991-2002

A Gjini; JM Stuart; DA Lawlor; KAV Cartwright; H Christensen; M Ramsay; RS Heyderman

doi:10.1017/s0950268805005595

Changing epidemiology of bacterial meningitis among adults in England and Wales 1991-2002

A Gjini, JM Stuart, DA Lawlor, KAV Cartwright, H Christensen, M Ramsay, RS Heyderman

Research output: Contribution to journal › Article (Academic Journal) › peer-review

25 Citations (Scopus)

Abstract

We examined the epidemiology of community-acquired bacterial meningitis among adults in England and Wales between 1991 and 2002. Among 3169 cases, meningococcal infection was predominant among young adults and pneumococcal meningitis among older adults. Whilst infection due to most causes decreased, the incidence of tuberculous (TB) meningitis doubled over the 12 years. The mortality rate among meningococcal and pneumococcal infections fell from 0.45/10(5) to 0.31/10(5) (P=0.0001). This study demonstrates important changes in the epidemiology of bacterial meningitis among UK adults. Improvements in clinical management, childhood vaccination programmes and the re-emergence of tuberculosis are likely to be drivers of these changes.

Translated title of the contribution	Changing epidemiology of bacterial meningitis among adults in England and Wales 1991-2002
Original language	English
Pages (from-to)	567 - 569
Number of pages	3
Journal	Epidemiology and Infection
Volume	134 (3)
DOIs	https://doi.org/10.1017/s0950268805005595
Publication status	Published - Jun 2006

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Publisher: Cambridge University Press

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title = "Changing epidemiology of bacterial meningitis among adults in England and Wales 1991-2002",

abstract = "We examined the epidemiology of community-acquired bacterial meningitis among adults in England and Wales between 1991 and 2002. Among 3169 cases, meningococcal infection was predominant among young adults and pneumococcal meningitis among older adults. Whilst infection due to most causes decreased, the incidence of tuberculous (TB) meningitis doubled over the 12 years. The mortality rate among meningococcal and pneumococcal infections fell from 0.45/10(5) to 0.31/10(5) (P=0.0001). This study demonstrates important changes in the epidemiology of bacterial meningitis among UK adults. Improvements in clinical management, childhood vaccination programmes and the re-emergence of tuberculosis are likely to be drivers of these changes.",

author = "A Gjini and JM Stuart and DA Lawlor and KAV Cartwright and H Christensen and M Ramsay and RS Heyderman",

note = "Publisher: Cambridge University Press",

year = "2006",

month = jun,

doi = "10.1017/s0950268805005595",

language = "English",

volume = "134 (3)",

pages = "567 -- 569",

journal = "Epidemiology and Infection",

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TY - JOUR

T1 - Changing epidemiology of bacterial meningitis among adults in England and Wales 1991-2002

AU - Gjini, A

AU - Stuart, JM

AU - Lawlor, DA

AU - Cartwright, KAV

AU - Christensen, H

AU - Ramsay, M

AU - Heyderman, RS

N1 - Publisher: Cambridge University Press

PY - 2006/6

Y1 - 2006/6

N2 - We examined the epidemiology of community-acquired bacterial meningitis among adults in England and Wales between 1991 and 2002. Among 3169 cases, meningococcal infection was predominant among young adults and pneumococcal meningitis among older adults. Whilst infection due to most causes decreased, the incidence of tuberculous (TB) meningitis doubled over the 12 years. The mortality rate among meningococcal and pneumococcal infections fell from 0.45/10(5) to 0.31/10(5) (P=0.0001). This study demonstrates important changes in the epidemiology of bacterial meningitis among UK adults. Improvements in clinical management, childhood vaccination programmes and the re-emergence of tuberculosis are likely to be drivers of these changes.

AB - We examined the epidemiology of community-acquired bacterial meningitis among adults in England and Wales between 1991 and 2002. Among 3169 cases, meningococcal infection was predominant among young adults and pneumococcal meningitis among older adults. Whilst infection due to most causes decreased, the incidence of tuberculous (TB) meningitis doubled over the 12 years. The mortality rate among meningococcal and pneumococcal infections fell from 0.45/10(5) to 0.31/10(5) (P=0.0001). This study demonstrates important changes in the epidemiology of bacterial meningitis among UK adults. Improvements in clinical management, childhood vaccination programmes and the re-emergence of tuberculosis are likely to be drivers of these changes.

U2 - 10.1017/s0950268805005595

DO - 10.1017/s0950268805005595

M3 - Article (Academic Journal)

SN - 1469-4409

VL - 134 (3)

SP - 567

EP - 569

JO - Epidemiology and Infection

JF - Epidemiology and Infection

ER -

Changing epidemiology of bacterial meningitis among adults in England and Wales 1991-2002

Abstract

Bibliographical note

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