Chapter 11 – Variation, Modification, and Reorganization of Broken Chromatin

Anna Chambers, Jessica Downs, Timothy Humphrey

Research output: Chapter in Book/Report/Conference proceedingChapter in a book


DNA damage occurs in the context of chromatin, and, of course, so do recognition and repair of the DNA lesions. It is well established that chromatin composition and dynamics play a central role in the cellular response to DNA damage and, in particular, to double-strand breaks (DSBs). Here, we review recent advances in the contribution of histone posttranslational modifications, histone variants, and chromatin remodeling enzymes to DSB responses.
Original languageEnglish
Title of host publicationChromatin Signaling and Diseases
PublisherAcademic Press
Publication statusPublished - Oct 2016


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