Characterisation of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus

ZA Bortolotto, GL Collingridge

Research output: Contribution to journalArticle (Academic Journal)peer-review

216 Citations (Scopus)

Abstract

The transient activation of the N-methyl-D-aspartate (NMDA) receptor system by high frequency (tetanic) stimulation results in a rapidly developing and long-lasting potentiation of synaptic transmission in the CA1 region of the hippocampus. This potentiation can be divided into an early decremental component, known as short-term potentiation (STP), and a more slowly developing persistent phase, termed long-term potentiation (LTP). Here we describe how activation of metabotropic glutamate receptors (mGluRs), by aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R-ACPD), can induce the same stable form of LTP, but without the STP component. 1S,3R-ACPD-induced LTP does not require electrical stimulation during its induction, but is dependent on an intact connection between the CA3 and CA1 regions of the hippocampus. 1S,3R-ACPD-induced LTP circumvents the need for the activation of NMDA receptors and is likely to involve both the stimulation of protein kinase C (PKC) and the release of Ca2+ from intracellular stores.
Translated title of the contributionCharacterisation of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalNeuropharmacology
Volume32
DOIs
Publication statusPublished - Jan 1993

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