Chemical communication in spatially organized protocell colonies and protocell/living cell micro-arrays

Xuejing Wang, Liangfei Tian, Hang Du, Mei Li, Wei Mu, Bruce W. Drinkwater, Xiaojun Han*, Stephen Mann

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)
54 Downloads (Pure)

Abstract

Micro-arrays of discrete or hemifused giant unilamellar lipid vesicles (GUVs) with controllable spatial geometries, lattice dimensions, trapped occupancies and compositions are prepared by acoustic standing wave patterning, and employed as platforms to implement chemical signaling in GUV colonies and protocell/living cell consortia. The methodology offers an alternative approach to GUV micro-array fabrication and provides new opportunities in protocell research and bottom-up synthetic biology.

Original languageEnglish
Pages (from-to)9446-9453
Number of pages8
JournalChemical Science
Volume10
Issue number41
Early online date18 Sep 2019
DOIs
Publication statusE-pub ahead of print - 18 Sep 2019

Structured keywords

  • BrisSynBio
  • Bristol BioDesign Institute

Keywords

  • Synthetic biology

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