Chemical mechanisms involved during the biosynthesis of tropolones

Russell J. Cox*, Ahmed Al-Fahad

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

20 Citations (Scopus)

Abstract

Tropolones are seven-membered aromatic rings which feature in the core of several important bioactive natural products including colchicine and stipitatic acid. Studies of their biosynthesis over nearly 70 years have revealed four parallel routes from polyketide, terpene, alkaloid and shikimate precursors, but the key steps all involve ring expansion of an alkylated 6-membered ring. Recent studies in fungi have revealed details of the individual chemical steps at the molecular level, but detailed molecular biosynthetic pathways in other organisms remain obscure.

Original languageEnglish
Pages (from-to)532-536
Number of pages5
JournalCurrent Opinion in Chemical Biology
Volume17
Issue number4
DOIs
Publication statusPublished - Aug 2013

Keywords

  • RING-EXPANSION
  • PENICILLIUM-STIPITATUM
  • ACID BIOSYNTHESIS
  • COLCHICINE
  • AUTUMNALINE
  • HYDROGENS
  • FATE

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