Projects per year
Abstract
Two novel α-linked sialyltrisaccharide imidazolium-type probes (ITags) based on the structures of biologically relevant 6'-sialyllactosamine and 3'-sialyllactosamine were efficiently and stereoselectively prepared using a chemo-enzymatic approach. The apparent kinetic parameters for the enzyme catalyzed transformations with α-2,3-sialyltransferase (α-2,3-ST) and α-2,6-sialyltransferase (α-2,6-ST) were measured by LC-MS using the ionic probes. This strategy demonstrates the suitability of the ITags to probe glycosyltransferase activity and their versatility in the preparation of sialylated epitopes for glycobiology research.
Original language | English |
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Pages (from-to) | 4329-32 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 25 |
Issue number | 19 |
DOIs | |
Publication status | Published - 1 Oct 2015 |
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Dive into the research topics of 'Chemo-enzymatic synthesis of imidazolium-tagged sialyllactosamine probes'. Together they form a unique fingerprint.Projects
- 3 Finished
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GLYCO-TOOLS: Bio-Inspire Tools for Glycoscience - ERC
Galan, M. C. (Principal Investigator)
1/07/15 → 31/12/20
Project: Research
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3-month Core Capability for Chemistry Research
Crosby, J. (Principal Investigator)
1/01/13 → 1/04/13
Project: Research
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Reworking of Novel tools for Glycoscience
Galan, M. C. (Principal Investigator)
31/03/12 → 30/08/17
Project: Research