Chemo-selective Rh-catalysed hydrogenation of azides into amines

Mattia Ghirardello, Helene Ledru, Abhijit Sau, M Carmen Galan

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

Rh/Al2O3 can be used as an effective chemo-selective reductive catalyst that combines the mild conditions of catalytic hydrogenation with high selectivity for azide moieties in the presence of other hydrogenolysis labile groups such as benzyl and benzyloxycarbonyl functionalities. The practicality of this strategy is exemplified with a range of azide-containing carbohydrate and amino acid derivatives.

Original languageEnglish
Pages (from-to)107948
Number of pages4
JournalCarbohydrate Research
Volume489
Early online date6 Feb 2020
DOIs
Publication statusE-pub ahead of print - 6 Feb 2020

Bibliographical note

Copyright © 2020. Published by Elsevier Ltd.

Keywords

  • Rhodium catalysis
  • Azide reduction
  • Chemo-selective reduction
  • Protecting groups manipulation
  • Aminoglycosides

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