Childhood Inflammatory Markers and Risks for Psychosis and Depression at Age 24: examination of temporality and specificity of association in a population-based prospective birth cohort

Benjamin I Perry; Stanley  Zammit; Peter B Jones; Golam M Khandaker

doi:10.1016/j.schres.2021.02.008

Childhood Inflammatory Markers and Risks for Psychosis and Depression at Age 24: examination of temporality and specificity of association in a population-based prospective birth cohort

Benjamin I Perry, Stanley Zammit, Peter B Jones, Golam M Khandaker

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Cross-sectional studies have reported elevated concentrations of inflammatory markers in psychosis and depression. However, questions regarding temporality and specificity of association, crucial for understanding the potential role of inflammation, remain.

Original language	English
Pages (from-to)	69-76
Number of pages	8
Journal	Schizophrenia Research
Volume	230
Early online date	5 Mar 2021
DOIs	https://doi.org/10.1016/j.schres.2021.02.008
Publication status	Published - 1 Apr 2021

Bibliographical note

Funding Information:
BIP acknowledges funding support from the NIHR (Doctoral Research Fellowship, DRF-2018-11-ST2-018 ). The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health and Social Care. GMK acknowledges funding support from the Wellcome Trust (Intermediate Clinical Fellowship; grant code: 201486/Z/16/Z ), the MQ: Transforming Mental Health (Data Science Award; grant code: MQDS17/40 ), the Medical Research Council UK (MICA: Mental Health Data Pathfinder; grant code: MC_PC_17213 and Therapeutic Target Validation in Mental Health; grant code: MR/S037675/1 ), and the BMA Foundation (J Moulton grant 2019). PBJ acknowledges funding from the MRC and MQ (as above), programmatic funding from NIHR ( RP-PG-0616-20003 ) and support from the Applied Research Collaboration East of England. SZ is supported by the NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol. The UK Medical Research Council and Wellcome Trust> (Grant no: 102215/2/13/2 ) and the University of Bristol provide core support for ALSPAC. A comprehensive list of grants funding is available on the ALSPAC website ( http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf/ ); this research was specifically funded by The Wellcome Trust (Grant no: 08426812/Z/07/Z ), Wellcome Trust & MRC (Grant no: 076467/Z/05/Z ) and MRC (Grant no: MR/M006727/1 ).

Publisher Copyright:
© 2021 The Authors

Keywords

IL-6
CRP
Inflammation
Longitudinal study
PsychosisDepression
ALSPAC

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10.1016/j.schres.2021.02.008

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title = "Childhood Inflammatory Markers and Risks for Psychosis and Depression at Age 24: examination of temporality and specificity of association in a population-based prospective birth cohort",

abstract = "Cross-sectional studies have reported elevated concentrations of inflammatory markers in psychosis and depression. However, questions regarding temporality and specificity of association, crucial for understanding the potential role of inflammation, remain. ",

keywords = "IL-6, CRP, Inflammation, Longitudinal study, PsychosisDepression, ALSPAC",

author = "Perry, {Benjamin I} and Stanley Zammit and Jones, {Peter B} and Khandaker, {Golam M}",

note = "Funding Information: BIP acknowledges funding support from the NIHR (Doctoral Research Fellowship, DRF-2018-11-ST2-018 ). The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health and Social Care. GMK acknowledges funding support from the Wellcome Trust (Intermediate Clinical Fellowship; grant code: 201486/Z/16/Z ), the MQ: Transforming Mental Health (Data Science Award; grant code: MQDS17/40 ), the Medical Research Council UK (MICA: Mental Health Data Pathfinder; grant code: MC_PC_17213 and Therapeutic Target Validation in Mental Health; grant code: MR/S037675/1 ), and the BMA Foundation (J Moulton grant 2019). PBJ acknowledges funding from the MRC and MQ (as above), programmatic funding from NIHR ( RP-PG-0616-20003 ) and support from the Applied Research Collaboration East of England. SZ is supported by the NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol. The UK Medical Research Council and Wellcome Trust> (Grant no: 102215/2/13/2 ) and the University of Bristol provide core support for ALSPAC. A comprehensive list of grants funding is available on the ALSPAC website ( http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf/ ); this research was specifically funded by The Wellcome Trust (Grant no: 08426812/Z/07/Z ), Wellcome Trust & MRC (Grant no: 076467/Z/05/Z ) and MRC (Grant no: MR/M006727/1 ). Publisher Copyright: {\textcopyright} 2021 The Authors",

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Childhood Inflammatory Markers and Risks for Psychosis and Depression at Age 24 : examination of temporality and specificity of association in a population-based prospective birth cohort. / Perry, Benjamin I; Zammit, Stanley ; Jones, Peter B et al.

In: Schizophrenia Research, Vol. 230, 01.04.2021, p. 69-76.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Childhood Inflammatory Markers and Risks for Psychosis and Depression at Age 24: examination of temporality and specificity of association in a population-based prospective birth cohort

Abstract

Bibliographical note

Keywords

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