Chitosan silk-based three-dimensional scaffolds containing gentamicin-encapsulated calcium alginate beads for drug administration and blood compatibility

Abijeet Singh Mehta, Brijesh K. Singh, Nandita Singh, D. Archana, Kirti Snigdha, Robert Harniman, Sameer S. Rahatekar, R. P. Tewari, P. K. Dutta*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

26 Citations (Scopus)

Abstract

In the present study gentamicin was encapsulated within calcium alginate beads and incorporated into porous chitosan, gelatin, double-hybrid silk fibroin, chitosan/gelatin and double-hybrid silk fibroin/chitosan scaffolds. Physiochemical, morphological and biological properties of fabricated amenable model systems were evaluated, revealing hemocompatible nature of double-hybrid silk fibroin/chitosan and double-hybrid silk fibroin scaffolds of hemolysis %<5 and porosity >85%. Fourier transform infrared results confirmed the blend formation and scanning electron microscope images showed good interconnectivity. Double-hybrid silk fibroin/chitosan-blended scaffold shows higher compressive strength and compressive modulus than other fabricated scaffolds. A comparative drug release profile of fabricated scaffolds revealed that double-hybrid silk fibroin/chitosan scaffold is a pertinent model system because of its prolonged drug release, optimal hemocompatability and high compressive modulus.

Original languageEnglish
Pages (from-to)1314-1325
Number of pages12
JournalJournal of Biomaterials Applications
Volume29
Issue number9
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • chitosan
  • drug delivery
  • gelatin
  • gentamicin
  • scaffolds
  • Silk fibroin

Fingerprint

Dive into the research topics of 'Chitosan silk-based three-dimensional scaffolds containing gentamicin-encapsulated calcium alginate beads for drug administration and blood compatibility'. Together they form a unique fingerprint.

Cite this