Abstract
AimsIn this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials.
Materials and methods CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure.
Results Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonisation by E. faecalis.
Conclusions CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonisation without affecting closure.
Materials and methods CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure.
Results Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonisation by E. faecalis.
Conclusions CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonisation without affecting closure.
| Original language | English |
|---|---|
| Pages (from-to) | 2049-2057 |
| Number of pages | 9 |
| Journal | Nanomedicine |
| Volume | 11 |
| Issue number | 16 |
| Early online date | 28 Jul 2016 |
| DOIs | |
| Publication status | Published - Aug 2016 |
Keywords
- Antimicrobial
- chlorhexidine
- catheter
- healing
- safety
- toxicity
- wound care
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Professor Michele E Barbour
- Senior Team - Associate Pro Vice-Chancellor (Enterprise & Innovation)
- Bristol Dental School - Professor of Biomaterials
- Infection and Immunity
Person: Academic , Member