Chlorhexidine hexametaphosphate as a wound care material coating: Antimicrobial efficacy, toxicity and effect on healing

Michele Barbour, Sarah Maddocks, Helena Grady, James Roper, Mark Bass, Andrew Collins, Rachel Dommett, Margaret Saunders

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)
318 Downloads (Pure)

Abstract

AimsIn this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. 
Materials and methods CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. 
Results Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonisation by E. faecalis
Conclusions CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonisation without affecting closure.
Original languageEnglish
Pages (from-to)2049-2057
Number of pages9
JournalNanomedicine
Volume11
Issue number16
Early online date28 Jul 2016
DOIs
Publication statusPublished - Aug 2016

Keywords

  • Antimicrobial
  • chlorhexidine
  • catheter
  • healing
  • safety
  • toxicity
  • wound care

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