Chlorhexidine hexametaphosphate as a wound care material coating: Antimicrobial efficacy, toxicity and effect on healing

Michele Barbour; Sarah Maddocks; Helena Grady; James Roper; Mark Bass; Andrew Collins; Rachel Dommett; Margaret Saunders

doi:10.2217/nnm-2016-0084

Chlorhexidine hexametaphosphate as a wound care material coating: Antimicrobial efficacy, toxicity and effect on healing

Michele Barbour, Sarah Maddocks, Helena Grady, James Roper, Mark Bass, Andrew Collins, Rachel Dommett, Margaret Saunders

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

AimsIn this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials.
Materials and methods CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure.
Results Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonisation by E. faecalis.
Conclusions CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonisation without affecting closure.

Original language	English
Pages (from-to)	2049-2057
Number of pages	9
Journal	Nanomedicine
Volume	11
Issue number	16
Early online date	28 Jul 2016
DOIs	https://doi.org/10.2217/nnm-2016-0084
Publication status	Published - Aug 2016

Research Groups and Themes

Bristol BioDesign Institute

Keywords

synthetic biology
catheter
safety
wound care
healing
toxicity
Antimicrobial
chlorhexidine

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Professor Michele E Barbour
- M.E.Barbourbristol.acuk
- Senior Team - Associate Pro Vice-Chancellor (Enterprise & Innovation)
- Bristol Dental School - Professor of Biomaterials
- Infection and Immunity
Person: Academic , Member, Professional and Administrative

Cite this

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title = "Chlorhexidine hexametaphosphate as a wound care material coating: Antimicrobial efficacy, toxicity and effect on healing",

abstract = "AimsIn this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials and methods CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Results Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonisation by E. faecalis. Conclusions CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonisation without affecting closure.",

keywords = "synthetic biology, catheter, safety, wound care, healing, toxicity, Antimicrobial, chlorhexidine",

author = "Michele Barbour and Sarah Maddocks and Helena Grady and James Roper and Mark Bass and Andrew Collins and Rachel Dommett and Margaret Saunders",

year = "2016",

month = aug,

doi = "10.2217/nnm-2016-0084",

language = "English",

volume = "11",

pages = "2049--2057",

journal = "Nanomedicine",

issn = "1743-5889",

publisher = "Taylor \& Francis Group",

number = "16",

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TY - JOUR

T1 - Chlorhexidine hexametaphosphate as a wound care material coating

T2 - Antimicrobial efficacy, toxicity and effect on healing

AU - Barbour, Michele

AU - Maddocks, Sarah

AU - Grady, Helena

AU - Roper, James

AU - Bass, Mark

AU - Collins, Andrew

AU - Dommett, Rachel

AU - Saunders, Margaret

PY - 2016/8

Y1 - 2016/8

N2 - AimsIn this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials and methods CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Results Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonisation by E. faecalis. Conclusions CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonisation without affecting closure.

AB - AimsIn this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials and methods CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Results Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonisation by E. faecalis. Conclusions CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonisation without affecting closure.

KW - synthetic biology

KW - catheter

KW - safety

KW - wound care

KW - healing

KW - toxicity

KW - Antimicrobial

KW - chlorhexidine

U2 - 10.2217/nnm-2016-0084

DO - 10.2217/nnm-2016-0084

M3 - Article (Academic Journal)

C2 - 27465012

SN - 1743-5889

VL - 11

SP - 2049

EP - 2057

JO - Nanomedicine

JF - Nanomedicine

IS - 16

ER -

Chlorhexidine hexametaphosphate as a wound care material coating: Antimicrobial efficacy, toxicity and effect on healing

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