Chromothripsis and cancer: causes and consequences of chromosome shattering

Josep V Forment; Abderrahmane Kaidi; Stephen P Jackson

doi:10.1038/nrc3352

Chromothripsis and cancer: causes and consequences of chromosome shattering

Josep V Forment, Abderrahmane Kaidi, Stephen P Jackson

Research output: Contribution to journal › Article (Academic Journal) › peer-review

307 Citations (Scopus)

Abstract

Genomic alterations that lead to oncogene activation and tumour suppressor loss are important driving forces for cancer development. Although these changes can accumulate progressively during cancer evolution, recent studies have revealed that many cancer cells harbour chromosomes bearing tens to hundreds of clustered genome rearrangements. In this Review, we describe how this striking phenomenon, termed chromothripsis, is likely to arise through chromosome breakage and inaccurate reassembly. We also discuss the potential diagnostic, prognostic and therapeutic implications of chromothripsis in cancer.

Original language	English
Pages (from-to)	663-70
Number of pages	8
Journal	Nature Reviews Cancer
Volume	12
Issue number	10
DOIs	https://doi.org/10.1038/nrc3352
Publication status	Published - Oct 2012

Keywords

Animals
Chromosome Aberrations
Chromosome Breakage
Chromosomes, Human
Chromosomes, Mammalian
DNA Repair
Gene Rearrangement
Genes, Tumor Suppressor
Humans
Neoplasms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Chromothripsis and cancer: causes and consequences of chromosome shattering",

abstract = "Genomic alterations that lead to oncogene activation and tumour suppressor loss are important driving forces for cancer development. Although these changes can accumulate progressively during cancer evolution, recent studies have revealed that many cancer cells harbour chromosomes bearing tens to hundreds of clustered genome rearrangements. In this Review, we describe how this striking phenomenon, termed chromothripsis, is likely to arise through chromosome breakage and inaccurate reassembly. We also discuss the potential diagnostic, prognostic and therapeutic implications of chromothripsis in cancer.",

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AU - Forment, Josep V

AU - Kaidi, Abderrahmane

AU - Jackson, Stephen P

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KW - Animals

KW - Chromosome Aberrations

KW - Chromosome Breakage

KW - Chromosomes, Human

KW - Chromosomes, Mammalian

KW - DNA Repair

KW - Gene Rearrangement

KW - Genes, Tumor Suppressor

KW - Humans

KW - Neoplasms

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DO - 10.1038/nrc3352

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EP - 670

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 10

ER -

Chromothripsis and cancer: causes and consequences of chromosome shattering

Abstract

Keywords

UN SDGs

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