Chromothripsis and cancer: causes and consequences of chromosome shattering

Josep V Forment, Abderrahmane Kaidi, Stephen P Jackson

Research output: Contribution to journalArticle (Academic Journal)

223 Citations (Scopus)

Abstract

Genomic alterations that lead to oncogene activation and tumour suppressor loss are important driving forces for cancer development. Although these changes can accumulate progressively during cancer evolution, recent studies have revealed that many cancer cells harbour chromosomes bearing tens to hundreds of clustered genome rearrangements. In this Review, we describe how this striking phenomenon, termed chromothripsis, is likely to arise through chromosome breakage and inaccurate reassembly. We also discuss the potential diagnostic, prognostic and therapeutic implications of chromothripsis in cancer.
Original languageEnglish
Pages (from-to)663-70
Number of pages8
JournalNature Reviews Cancer
Volume12
Issue number10
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Animals
  • Chromosome Aberrations
  • Chromosome Breakage
  • Chromosomes, Human
  • Chromosomes, Mammalian
  • DNA Repair
  • Gene Rearrangement
  • Genes, Tumor Suppressor
  • Humans
  • Neoplasms

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