Abstract
Genomic alterations that lead to oncogene activation and tumour suppressor loss are important driving forces for cancer development. Although these changes can accumulate progressively during cancer evolution, recent studies have revealed that many cancer cells harbour chromosomes bearing tens to hundreds of clustered genome rearrangements. In this Review, we describe how this striking phenomenon, termed chromothripsis, is likely to arise through chromosome breakage and inaccurate reassembly. We also discuss the potential diagnostic, prognostic and therapeutic implications of chromothripsis in cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 663-70 |
| Number of pages | 8 |
| Journal | Nature Reviews Cancer |
| Volume | 12 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2012 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Animals
- Chromosome Aberrations
- Chromosome Breakage
- Chromosomes, Human
- Chromosomes, Mammalian
- DNA Repair
- Gene Rearrangement
- Genes, Tumor Suppressor
- Humans
- Neoplasms
Fingerprint
Dive into the research topics of 'Chromothripsis and cancer: causes and consequences of chromosome shattering'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver